Cargando…
Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study
Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to e...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928852/ https://www.ncbi.nlm.nih.gov/pubmed/36818655 http://dx.doi.org/10.3389/fnmol.2023.1128429 |
_version_ | 1784888726520856576 |
---|---|
author | Mei, Yang Chen, Qi Li, Yu-Ping Chen, Yao-hua Xia, Juan Zeng, Jie Yu, Le-hua Li, Wei Cui, Jian |
author_facet | Mei, Yang Chen, Qi Li, Yu-Ping Chen, Yao-hua Xia, Juan Zeng, Jie Yu, Le-hua Li, Wei Cui, Jian |
author_sort | Mei, Yang |
collection | PubMed |
description | Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to explore the relationship between genetic polymorphisms of AMPK gene (Rs13361707, rs3792822, and rs10074991) in PRKAA1 and postherpetic neuralgia (PHN) in Chinese individuals. Hundred and thirty two patients with PHN and 118 control individuals were enrolled in this study. All blood samples were shuffled and blinded to the person performing the haplotype analysis. Rs13361707, rs3792822, and rs10074991 PRKAA1 genotypes were identified in all participants. Dominant and recessive models were used for evaluating the association between these nucleotide polymorphisms and PHN susceptibility. A haplotype analysis of PHN patients and healthy controls was performed. Clinical characteristics between the two groups were not significantly different (p > 0.05) except that the ages in control subjects were younger than the PHN patients (p < 0.05). Genotypes and allele frequencies are significantly different between the PHN patients and control subjects for the rs13361707 and rs10074991 polymorphisms (p < 0.05), but not for rs3792822 (p > 0.05). In addition, the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence, but TCA was positively correlated with PHN (p < 0.05). Our results indicate that PRKAA1 gene polymorphisms rs13361707 and rs10074991 were associated with a risk of PHN, and that the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence in haplotype analysis. TCA was positively associated with PHN in Chinese individuals. |
format | Online Article Text |
id | pubmed-9928852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99288522023-02-16 Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study Mei, Yang Chen, Qi Li, Yu-Ping Chen, Yao-hua Xia, Juan Zeng, Jie Yu, Le-hua Li, Wei Cui, Jian Front Mol Neurosci Molecular Neuroscience Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to explore the relationship between genetic polymorphisms of AMPK gene (Rs13361707, rs3792822, and rs10074991) in PRKAA1 and postherpetic neuralgia (PHN) in Chinese individuals. Hundred and thirty two patients with PHN and 118 control individuals were enrolled in this study. All blood samples were shuffled and blinded to the person performing the haplotype analysis. Rs13361707, rs3792822, and rs10074991 PRKAA1 genotypes were identified in all participants. Dominant and recessive models were used for evaluating the association between these nucleotide polymorphisms and PHN susceptibility. A haplotype analysis of PHN patients and healthy controls was performed. Clinical characteristics between the two groups were not significantly different (p > 0.05) except that the ages in control subjects were younger than the PHN patients (p < 0.05). Genotypes and allele frequencies are significantly different between the PHN patients and control subjects for the rs13361707 and rs10074991 polymorphisms (p < 0.05), but not for rs3792822 (p > 0.05). In addition, the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence, but TCA was positively correlated with PHN (p < 0.05). Our results indicate that PRKAA1 gene polymorphisms rs13361707 and rs10074991 were associated with a risk of PHN, and that the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence in haplotype analysis. TCA was positively associated with PHN in Chinese individuals. Frontiers Media S.A. 2023-02-01 /pmc/articles/PMC9928852/ /pubmed/36818655 http://dx.doi.org/10.3389/fnmol.2023.1128429 Text en Copyright © 2023 Mei, Chen, Li, Chen, Xia, Zeng, Yu, Li and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Mei, Yang Chen, Qi Li, Yu-Ping Chen, Yao-hua Xia, Juan Zeng, Jie Yu, Le-hua Li, Wei Cui, Jian Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title | Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title_full | Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title_fullStr | Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title_full_unstemmed | Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title_short | Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study |
title_sort | genetic polymorphisms of prkaa1 (ampkα1) and postherpetic pain susceptibility: multicenter, randomized control, and haplotype analysis study |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928852/ https://www.ncbi.nlm.nih.gov/pubmed/36818655 http://dx.doi.org/10.3389/fnmol.2023.1128429 |
work_keys_str_mv | AT meiyang geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT chenqi geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT liyuping geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT chenyaohua geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT xiajuan geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT zengjie geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT yulehua geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT liwei geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy AT cuijian geneticpolymorphismsofprkaa1ampka1andpostherpeticpainsusceptibilitymulticenterrandomizedcontrolandhaplotypeanalysisstudy |