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Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope

BACKGROUND: The relationship between patent foramen ovale (PFO) and unexplained syncope remains to be illustrated. Therefore, this study aimed to explore the outcomes and prognostic factors for syncope recurrence after PFO closure. METHODS: Patients with both large right-to-left shunting (RLS) PFO a...

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Autores principales: Wang, Xianwen, Liu, Xiangwei, Zheng, Lulu, Liu, Yubo, Guan, Zhengyan, Dai, Jingyi, Chen, Xiaobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928853/
https://www.ncbi.nlm.nih.gov/pubmed/36816564
http://dx.doi.org/10.3389/fneur.2023.1104621
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author Wang, Xianwen
Liu, Xiangwei
Zheng, Lulu
Liu, Yubo
Guan, Zhengyan
Dai, Jingyi
Chen, Xiaobin
author_facet Wang, Xianwen
Liu, Xiangwei
Zheng, Lulu
Liu, Yubo
Guan, Zhengyan
Dai, Jingyi
Chen, Xiaobin
author_sort Wang, Xianwen
collection PubMed
description BACKGROUND: The relationship between patent foramen ovale (PFO) and unexplained syncope remains to be illustrated. Therefore, this study aimed to explore the outcomes and prognostic factors for syncope recurrence after PFO closure. METHODS: Patients with both large right-to-left shunting (RLS) PFO and unexplained syncope who visited the cardiovascular department of Xiangya Hospital Central South University from 1 January 2017 to 31 December 2021 were consecutively enrolled in our study. The recurrence rate of syncope was compared between the non-closure group (n = 20) and the closure group (n = 91). RESULTS: A total of 111 patients were finally included. After 31.11 ± 14.30 months of follow-up, only 11% of patients in the closure group had recurrent syncope, which was much lower than that of the non-closure group (11.0 vs. 35%, P = 0.018). We further investigated the possible prognostic factors for syncope recurrence in the closure group and found syncope occurring more than five times preoperatively, hypertension, and residual RLS at 12-month follow-up were significantly correlated with a higher number of recurrences. CONCLUSIONS: PFO closure reduced the recurrence rate of unexplained syncope. The efficacy of prevention was prognosticated by factors including the presence or absence of syncope induction, the frequency of syncope episodes, and the presence or absence of hypertension. Syncope recurrence was also related to residual shunts post closure.
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spelling pubmed-99288532023-02-16 Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope Wang, Xianwen Liu, Xiangwei Zheng, Lulu Liu, Yubo Guan, Zhengyan Dai, Jingyi Chen, Xiaobin Front Neurol Neurology BACKGROUND: The relationship between patent foramen ovale (PFO) and unexplained syncope remains to be illustrated. Therefore, this study aimed to explore the outcomes and prognostic factors for syncope recurrence after PFO closure. METHODS: Patients with both large right-to-left shunting (RLS) PFO and unexplained syncope who visited the cardiovascular department of Xiangya Hospital Central South University from 1 January 2017 to 31 December 2021 were consecutively enrolled in our study. The recurrence rate of syncope was compared between the non-closure group (n = 20) and the closure group (n = 91). RESULTS: A total of 111 patients were finally included. After 31.11 ± 14.30 months of follow-up, only 11% of patients in the closure group had recurrent syncope, which was much lower than that of the non-closure group (11.0 vs. 35%, P = 0.018). We further investigated the possible prognostic factors for syncope recurrence in the closure group and found syncope occurring more than five times preoperatively, hypertension, and residual RLS at 12-month follow-up were significantly correlated with a higher number of recurrences. CONCLUSIONS: PFO closure reduced the recurrence rate of unexplained syncope. The efficacy of prevention was prognosticated by factors including the presence or absence of syncope induction, the frequency of syncope episodes, and the presence or absence of hypertension. Syncope recurrence was also related to residual shunts post closure. Frontiers Media S.A. 2023-02-01 /pmc/articles/PMC9928853/ /pubmed/36816564 http://dx.doi.org/10.3389/fneur.2023.1104621 Text en Copyright © 2023 Wang, Liu, Zheng, Liu, Guan, Dai and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Xianwen
Liu, Xiangwei
Zheng, Lulu
Liu, Yubo
Guan, Zhengyan
Dai, Jingyi
Chen, Xiaobin
Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title_full Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title_fullStr Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title_full_unstemmed Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title_short Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
title_sort correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928853/
https://www.ncbi.nlm.nih.gov/pubmed/36816564
http://dx.doi.org/10.3389/fneur.2023.1104621
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