Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia

Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin–angiotensin–aldosterone system (RAAS) is one of the first to recognize preg...

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Autores principales: Artemieva, K. A., Nizyaeva, N. V., Baev, O. R., Romanov, A. Yu., Khlestova, G. V., Boltovskaya, M. N., Shchegolev, A. I., Kakturskiy, L. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928934/
https://www.ncbi.nlm.nih.gov/pubmed/36580212
http://dx.doi.org/10.1134/S1607672922060011
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author Artemieva, K. A.
Nizyaeva, N. V.
Baev, O. R.
Romanov, A. Yu.
Khlestova, G. V.
Boltovskaya, M. N.
Shchegolev, A. I.
Kakturskiy, L. V.
author_facet Artemieva, K. A.
Nizyaeva, N. V.
Baev, O. R.
Romanov, A. Yu.
Khlestova, G. V.
Boltovskaya, M. N.
Shchegolev, A. I.
Kakturskiy, L. V.
author_sort Artemieva, K. A.
collection PubMed
description Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin–angiotensin–aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases.
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spelling pubmed-99289342023-02-16 Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia Artemieva, K. A. Nizyaeva, N. V. Baev, O. R. Romanov, A. Yu. Khlestova, G. V. Boltovskaya, M. N. Shchegolev, A. I. Kakturskiy, L. V. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin–angiotensin–aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases. Pleiades Publishing 2022-12-29 2022 /pmc/articles/PMC9928934/ /pubmed/36580212 http://dx.doi.org/10.1134/S1607672922060011 Text en © The Author(s) 2022, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 507, pp. 256–263. © The Author(s), 2022. This article is an open access publication.ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022. © The Author(s), 2022. This article is an open access publication.Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 507, pp. 475–482. https://creativecommons.org/licenses/by/4.0/Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Artemieva, K. A.
Nizyaeva, N. V.
Baev, O. R.
Romanov, A. Yu.
Khlestova, G. V.
Boltovskaya, M. N.
Shchegolev, A. I.
Kakturskiy, L. V.
Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title_full Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title_fullStr Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title_full_unstemmed Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title_short Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
title_sort regulation of the placental renin-angiotensin-aldosterone system in early- and late-onset preeclampsia
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928934/
https://www.ncbi.nlm.nih.gov/pubmed/36580212
http://dx.doi.org/10.1134/S1607672922060011
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