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Regulatory effects of oral microbe on intestinal microbiota and the illness

Over the past decade, the association between oral health, intestinal microbiota, and systemic diseases has been further validated. Some oral microbial species have been isolated from pathological intestine mucosa or feces and identified as biomarkers for intestinal diseases. A small proportion of o...

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Autores principales: Lu, Yanbei, Li, Zhengyi, Peng, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928999/
https://www.ncbi.nlm.nih.gov/pubmed/36816583
http://dx.doi.org/10.3389/fcimb.2023.1093967
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author Lu, Yanbei
Li, Zhengyi
Peng, Xian
author_facet Lu, Yanbei
Li, Zhengyi
Peng, Xian
author_sort Lu, Yanbei
collection PubMed
description Over the past decade, the association between oral health, intestinal microbiota, and systemic diseases has been further validated. Some oral microbial species have been isolated from pathological intestine mucosa or feces and identified as biomarkers for intestinal diseases. A small proportion of oral microbiome passes through or colonizes the lower gastrointestinal tract, even in healthy individuals. Opportunistic pathogens from the oral cavity may expand and participate in the occurrence and progression of intestinal diseases when the anatomical barrier is disrupted. These disruptors interact with the intestinal microbiota, disturbing indigenous microorganisms, and mucosal barriers through direct colonization, blood circulation, or derived metabolite pathways. While interacting with the host’s immune system, oral-derived pathogens stimulate inflammation responses and guide the transition of the intestinal microenvironment from a healthy state to a pre-disease state. Therefore, the oral-gut microbiome axis sheds light on new clinical therapy options, and gastrointestinal tract ecology balance necessitates simultaneous consideration of both oral and gut microbiomes. This review summarizes possible routes of oral microbes entering the intestine and the effects of certain oral bacteria on intestinal microbiota and the host’s immune responses.
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spelling pubmed-99289992023-02-16 Regulatory effects of oral microbe on intestinal microbiota and the illness Lu, Yanbei Li, Zhengyi Peng, Xian Front Cell Infect Microbiol Cellular and Infection Microbiology Over the past decade, the association between oral health, intestinal microbiota, and systemic diseases has been further validated. Some oral microbial species have been isolated from pathological intestine mucosa or feces and identified as biomarkers for intestinal diseases. A small proportion of oral microbiome passes through or colonizes the lower gastrointestinal tract, even in healthy individuals. Opportunistic pathogens from the oral cavity may expand and participate in the occurrence and progression of intestinal diseases when the anatomical barrier is disrupted. These disruptors interact with the intestinal microbiota, disturbing indigenous microorganisms, and mucosal barriers through direct colonization, blood circulation, or derived metabolite pathways. While interacting with the host’s immune system, oral-derived pathogens stimulate inflammation responses and guide the transition of the intestinal microenvironment from a healthy state to a pre-disease state. Therefore, the oral-gut microbiome axis sheds light on new clinical therapy options, and gastrointestinal tract ecology balance necessitates simultaneous consideration of both oral and gut microbiomes. This review summarizes possible routes of oral microbes entering the intestine and the effects of certain oral bacteria on intestinal microbiota and the host’s immune responses. Frontiers Media S.A. 2023-02-01 /pmc/articles/PMC9928999/ /pubmed/36816583 http://dx.doi.org/10.3389/fcimb.2023.1093967 Text en Copyright © 2023 Lu, Li and Peng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Lu, Yanbei
Li, Zhengyi
Peng, Xian
Regulatory effects of oral microbe on intestinal microbiota and the illness
title Regulatory effects of oral microbe on intestinal microbiota and the illness
title_full Regulatory effects of oral microbe on intestinal microbiota and the illness
title_fullStr Regulatory effects of oral microbe on intestinal microbiota and the illness
title_full_unstemmed Regulatory effects of oral microbe on intestinal microbiota and the illness
title_short Regulatory effects of oral microbe on intestinal microbiota and the illness
title_sort regulatory effects of oral microbe on intestinal microbiota and the illness
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928999/
https://www.ncbi.nlm.nih.gov/pubmed/36816583
http://dx.doi.org/10.3389/fcimb.2023.1093967
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