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A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor
The human olfactory system comprises olfactory receptor neurons, projection neurons, and interneurons that perform remarkably sophisticated functions, including sensing, filtration, memorization, and forgetting of chemical stimuli for perception. Developing an artificial olfactory system that can mi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929093/ https://www.ncbi.nlm.nih.gov/pubmed/36788242 http://dx.doi.org/10.1038/s41467-023-36480-6 |
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author | Chouhdry, Hamna Haq Lee, Dong Hyun Bag, Atanu Lee, Nae-Eung |
author_facet | Chouhdry, Hamna Haq Lee, Dong Hyun Bag, Atanu Lee, Nae-Eung |
author_sort | Chouhdry, Hamna Haq |
collection | PubMed |
description | The human olfactory system comprises olfactory receptor neurons, projection neurons, and interneurons that perform remarkably sophisticated functions, including sensing, filtration, memorization, and forgetting of chemical stimuli for perception. Developing an artificial olfactory system that can mimic these functions has proved to be challenging. Herein, inspired by the neuronal network inside the glomerulus of the olfactory bulb, we present an artificial chemosensory neuronal synapse that can sense chemical stimuli and mimic the functions of excitatory and inhibitory neurotransmitter release in the synapses between olfactory receptor neurons, projection neurons, and interneurons. The proposed device is based on a flexible organic electrochemical transistor gated by the potential generated by the interaction of gas molecules with ions in a chemoreceptive ionogel. The combined use of a chemoreceptive ionogel and an organic semiconductor channel allows for a long retentive memory in response to chemical stimuli. Long-term memorization of the excitatory chemical stimulus can be also erased by applying an inhibitory electrical stimulus due to ion dynamics in the chemoresponsive ionogel gate electrolyte. Applying a simple device design, we were able to mimic the excitatory and inhibitory synaptic functions of chemical synapses in the olfactory system, which can further advance the development of artificial neuronal systems for biomimetic chemosensory applications. |
format | Online Article Text |
id | pubmed-9929093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99290932023-02-16 A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor Chouhdry, Hamna Haq Lee, Dong Hyun Bag, Atanu Lee, Nae-Eung Nat Commun Article The human olfactory system comprises olfactory receptor neurons, projection neurons, and interneurons that perform remarkably sophisticated functions, including sensing, filtration, memorization, and forgetting of chemical stimuli for perception. Developing an artificial olfactory system that can mimic these functions has proved to be challenging. Herein, inspired by the neuronal network inside the glomerulus of the olfactory bulb, we present an artificial chemosensory neuronal synapse that can sense chemical stimuli and mimic the functions of excitatory and inhibitory neurotransmitter release in the synapses between olfactory receptor neurons, projection neurons, and interneurons. The proposed device is based on a flexible organic electrochemical transistor gated by the potential generated by the interaction of gas molecules with ions in a chemoreceptive ionogel. The combined use of a chemoreceptive ionogel and an organic semiconductor channel allows for a long retentive memory in response to chemical stimuli. Long-term memorization of the excitatory chemical stimulus can be also erased by applying an inhibitory electrical stimulus due to ion dynamics in the chemoresponsive ionogel gate electrolyte. Applying a simple device design, we were able to mimic the excitatory and inhibitory synaptic functions of chemical synapses in the olfactory system, which can further advance the development of artificial neuronal systems for biomimetic chemosensory applications. Nature Publishing Group UK 2023-02-14 /pmc/articles/PMC9929093/ /pubmed/36788242 http://dx.doi.org/10.1038/s41467-023-36480-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chouhdry, Hamna Haq Lee, Dong Hyun Bag, Atanu Lee, Nae-Eung A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title | A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title_full | A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title_fullStr | A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title_full_unstemmed | A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title_short | A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
title_sort | flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929093/ https://www.ncbi.nlm.nih.gov/pubmed/36788242 http://dx.doi.org/10.1038/s41467-023-36480-6 |
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