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Graft rejection episodes after keratoplasty in Japanese eyes

We aimed to investigate the clinical characteristics and risk factors for graft rejection after keratoplasty in Japanese patients. We enrolled 730 cases (566 patients) of penetrating keratoplasty (PK, N = 198), Descemet’s stripping automated endothelial keratoplasty (DSAEK, N = 277), non-Descemet’s...

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Autores principales: Wajima, Haguku, Hayashi, Takahiko, Kobayashi, Akira, Nishino, Tsubasa, Mori, Natsuko, Yokogawa, Hideaki, Yamagami, Satoru, Sugiyama, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929100/
https://www.ncbi.nlm.nih.gov/pubmed/36788300
http://dx.doi.org/10.1038/s41598-023-29659-w
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author Wajima, Haguku
Hayashi, Takahiko
Kobayashi, Akira
Nishino, Tsubasa
Mori, Natsuko
Yokogawa, Hideaki
Yamagami, Satoru
Sugiyama, Kazuhisa
author_facet Wajima, Haguku
Hayashi, Takahiko
Kobayashi, Akira
Nishino, Tsubasa
Mori, Natsuko
Yokogawa, Hideaki
Yamagami, Satoru
Sugiyama, Kazuhisa
author_sort Wajima, Haguku
collection PubMed
description We aimed to investigate the clinical characteristics and risk factors for graft rejection after keratoplasty in Japanese patients. We enrolled 730 cases (566 patients) of penetrating keratoplasty (PK, N = 198), Descemet’s stripping automated endothelial keratoplasty (DSAEK, N = 277), non-Descemet’s stripping automated endothelial keratoplasty (nDSAEK, N = 138), and Descemet membrane endothelial keratoplasty (DMEK, N = 117). The incidence, clinical characteristics, and possible risk factors for graft rejection were analyzed. Graft rejection occurred in 65 cases (56 patients, 8.9%). The incidence rate of rejection was highest with PK (3.45/100 person-years), followed by DSAEK (2.34), nDSAEK (1.55), and DMEK (0.24). Cox regression analysis revealed keratoplasty type, younger age, indications (such as failed keratoplasty and infection), and steroid eyedrop use as possible risk factors. In the multivariate model adjusting baseline characteristics, PK and DSAEK had significantly higher hazard ratios (HRs) than DMEK (HR = 13.6, 95% confidence interval [CI] [1.83, 101] for PK, 7.77 [1.03, 58.6] for DSAEK). Although not statistically significant, the HR estimate of nDSAEK to DMEK (HR = 7.64, 95% CI [0.98, 59.6]) indicated higher HR in nDSAEK than in DMEK. DMEK is the favorable option among the four surgical procedures to avoid graft rejection after keratoplasty.
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spelling pubmed-99291002023-02-16 Graft rejection episodes after keratoplasty in Japanese eyes Wajima, Haguku Hayashi, Takahiko Kobayashi, Akira Nishino, Tsubasa Mori, Natsuko Yokogawa, Hideaki Yamagami, Satoru Sugiyama, Kazuhisa Sci Rep Article We aimed to investigate the clinical characteristics and risk factors for graft rejection after keratoplasty in Japanese patients. We enrolled 730 cases (566 patients) of penetrating keratoplasty (PK, N = 198), Descemet’s stripping automated endothelial keratoplasty (DSAEK, N = 277), non-Descemet’s stripping automated endothelial keratoplasty (nDSAEK, N = 138), and Descemet membrane endothelial keratoplasty (DMEK, N = 117). The incidence, clinical characteristics, and possible risk factors for graft rejection were analyzed. Graft rejection occurred in 65 cases (56 patients, 8.9%). The incidence rate of rejection was highest with PK (3.45/100 person-years), followed by DSAEK (2.34), nDSAEK (1.55), and DMEK (0.24). Cox regression analysis revealed keratoplasty type, younger age, indications (such as failed keratoplasty and infection), and steroid eyedrop use as possible risk factors. In the multivariate model adjusting baseline characteristics, PK and DSAEK had significantly higher hazard ratios (HRs) than DMEK (HR = 13.6, 95% confidence interval [CI] [1.83, 101] for PK, 7.77 [1.03, 58.6] for DSAEK). Although not statistically significant, the HR estimate of nDSAEK to DMEK (HR = 7.64, 95% CI [0.98, 59.6]) indicated higher HR in nDSAEK than in DMEK. DMEK is the favorable option among the four surgical procedures to avoid graft rejection after keratoplasty. Nature Publishing Group UK 2023-02-14 /pmc/articles/PMC9929100/ /pubmed/36788300 http://dx.doi.org/10.1038/s41598-023-29659-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wajima, Haguku
Hayashi, Takahiko
Kobayashi, Akira
Nishino, Tsubasa
Mori, Natsuko
Yokogawa, Hideaki
Yamagami, Satoru
Sugiyama, Kazuhisa
Graft rejection episodes after keratoplasty in Japanese eyes
title Graft rejection episodes after keratoplasty in Japanese eyes
title_full Graft rejection episodes after keratoplasty in Japanese eyes
title_fullStr Graft rejection episodes after keratoplasty in Japanese eyes
title_full_unstemmed Graft rejection episodes after keratoplasty in Japanese eyes
title_short Graft rejection episodes after keratoplasty in Japanese eyes
title_sort graft rejection episodes after keratoplasty in japanese eyes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929100/
https://www.ncbi.nlm.nih.gov/pubmed/36788300
http://dx.doi.org/10.1038/s41598-023-29659-w
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