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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023)
Quorum Sensing Inhibitor In article number 2204443, Martin Empting and colleagues describe the medicinal‐chemistry‐driven discovery of a new quorum sensing inhibitor (QSI) against Pseudomonas aeruginosa. The discovered QSI synergized with standard‐of‐care antibiotic tobramycin in a murine infection...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929108/ http://dx.doi.org/10.1002/advs.202370027 |
| _version_ | 1784888776062926848 |
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| author | Hamed, Mostafa M. Abdelsamie, Ahmed S. Rox, Katharina Schütz, Christian Kany, Andreas M. Röhrig, Teresa Schmelz, Stefan Blankenfeldt, Wulf Arce‐Rodriguez, Alejandro Borrero‐de Acuña, José Manuel Jahn, Dieter Rademacher, Jessica Ringshausen, Felix C. Cramer, Nina Tümmler, Burkhard Hirsch, Anna K. H. Hartmann, Rolf W. Empting, Martin |
| author_facet | Hamed, Mostafa M. Abdelsamie, Ahmed S. Rox, Katharina Schütz, Christian Kany, Andreas M. Röhrig, Teresa Schmelz, Stefan Blankenfeldt, Wulf Arce‐Rodriguez, Alejandro Borrero‐de Acuña, José Manuel Jahn, Dieter Rademacher, Jessica Ringshausen, Felix C. Cramer, Nina Tümmler, Burkhard Hirsch, Anna K. H. Hartmann, Rolf W. Empting, Martin |
| author_sort | Hamed, Mostafa M. |
| collection | PubMed |
| description | Quorum Sensing Inhibitor In article number 2204443, Martin Empting and colleagues describe the medicinal‐chemistry‐driven discovery of a new quorum sensing inhibitor (QSI) against Pseudomonas aeruginosa. The discovered QSI synergized with standard‐of‐care antibiotic tobramycin in a murine infection model providing an in vivo proof‐of‐concept. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9929108 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99291082023-02-16 Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) Hamed, Mostafa M. Abdelsamie, Ahmed S. Rox, Katharina Schütz, Christian Kany, Andreas M. Röhrig, Teresa Schmelz, Stefan Blankenfeldt, Wulf Arce‐Rodriguez, Alejandro Borrero‐de Acuña, José Manuel Jahn, Dieter Rademacher, Jessica Ringshausen, Felix C. Cramer, Nina Tümmler, Burkhard Hirsch, Anna K. H. Hartmann, Rolf W. Empting, Martin Adv Sci (Weinh) Frontispiece Quorum Sensing Inhibitor In article number 2204443, Martin Empting and colleagues describe the medicinal‐chemistry‐driven discovery of a new quorum sensing inhibitor (QSI) against Pseudomonas aeruginosa. The discovered QSI synergized with standard‐of‐care antibiotic tobramycin in a murine infection model providing an in vivo proof‐of‐concept. [Image: see text] John Wiley and Sons Inc. 2023-02-14 /pmc/articles/PMC9929108/ http://dx.doi.org/10.1002/advs.202370027 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Frontispiece Hamed, Mostafa M. Abdelsamie, Ahmed S. Rox, Katharina Schütz, Christian Kany, Andreas M. Röhrig, Teresa Schmelz, Stefan Blankenfeldt, Wulf Arce‐Rodriguez, Alejandro Borrero‐de Acuña, José Manuel Jahn, Dieter Rademacher, Jessica Ringshausen, Felix C. Cramer, Nina Tümmler, Burkhard Hirsch, Anna K. H. Hartmann, Rolf W. Empting, Martin Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title | Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title_full | Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title_fullStr | Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title_full_unstemmed | Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title_short | Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023) |
| title_sort | towards translation of pqsr inverse agonists: from in vitro efficacy optimization to in vivo proof‐of‐principle (adv. sci. 5/2023) |
| topic | Frontispiece |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929108/ http://dx.doi.org/10.1002/advs.202370027 |
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