Cargando…

Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control

Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self‐propelled property, and Ca(2+) release ability, for irregularly shaped and noncompress...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Qiao, Su, Baihai, Zhao, Weifeng, Zhao, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929117/
https://www.ncbi.nlm.nih.gov/pubmed/36567271
http://dx.doi.org/10.1002/advs.202205989
_version_ 1784888778284859392
author Yu, Qiao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
author_facet Yu, Qiao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
author_sort Yu, Qiao
collection PubMed
description Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self‐propelled property, and Ca(2+) release ability, for irregularly shaped and noncompressible hemorrhage. Herein, Janus self‐propelled chitosan‐based hydrogel with CaCO(3) (J‐CMH@CaCO(3)) is developed by partial ionic crosslinking of carboxylated chitosan (CCS) and Ca(2+), gravity settlement, and photopolymerization, followed by removing the shell of CCS. The obtained J‐CMH@CaCO(3) is further used as a hemostat powered by the internal CaCO(3) and coordinated protonated tranexamic acid (J‐CMH@CaCO(3)/T). Bubbles are generated and detached to provide the driving force, accompanied by the release of Ca(2+). The two aspects work in synergy to accelerate clot formation, endowing the J‐CMH@CaCO(3)/T with excellent hemostatic efficiency. The J‐CMH@CaCO(3)/T presents high blood absorption, favorable blood‐clotting ability, desired erythrocyte and platelet aggregation, and acceptable hemocompatibility and cytocompatibility. In rodent and rabbit bleeding models, the J‐CMH@CaCO(3)/T exhibits the most effective hemostasis to the best knowledge of the authors, wherein the hemorrhage is rapidly halted within 39 s. It is believed that the J‐CMH@CaCO(3)/T with self‐propelled property opens up a new avenue to design high‐performance hemostats for clinical application.
format Online
Article
Text
id pubmed-9929117
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-99291172023-02-16 Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control Yu, Qiao Su, Baihai Zhao, Weifeng Zhao, Changsheng Adv Sci (Weinh) Research Articles Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self‐propelled property, and Ca(2+) release ability, for irregularly shaped and noncompressible hemorrhage. Herein, Janus self‐propelled chitosan‐based hydrogel with CaCO(3) (J‐CMH@CaCO(3)) is developed by partial ionic crosslinking of carboxylated chitosan (CCS) and Ca(2+), gravity settlement, and photopolymerization, followed by removing the shell of CCS. The obtained J‐CMH@CaCO(3) is further used as a hemostat powered by the internal CaCO(3) and coordinated protonated tranexamic acid (J‐CMH@CaCO(3)/T). Bubbles are generated and detached to provide the driving force, accompanied by the release of Ca(2+). The two aspects work in synergy to accelerate clot formation, endowing the J‐CMH@CaCO(3)/T with excellent hemostatic efficiency. The J‐CMH@CaCO(3)/T presents high blood absorption, favorable blood‐clotting ability, desired erythrocyte and platelet aggregation, and acceptable hemocompatibility and cytocompatibility. In rodent and rabbit bleeding models, the J‐CMH@CaCO(3)/T exhibits the most effective hemostasis to the best knowledge of the authors, wherein the hemorrhage is rapidly halted within 39 s. It is believed that the J‐CMH@CaCO(3)/T with self‐propelled property opens up a new avenue to design high‐performance hemostats for clinical application. John Wiley and Sons Inc. 2022-12-25 /pmc/articles/PMC9929117/ /pubmed/36567271 http://dx.doi.org/10.1002/advs.202205989 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Yu, Qiao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title_full Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title_fullStr Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title_full_unstemmed Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title_short Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control
title_sort janus self‐propelled chitosan‐based hydrogel spheres for rapid bleeding control
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929117/
https://www.ncbi.nlm.nih.gov/pubmed/36567271
http://dx.doi.org/10.1002/advs.202205989
work_keys_str_mv AT yuqiao janusselfpropelledchitosanbasedhydrogelspheresforrapidbleedingcontrol
AT subaihai janusselfpropelledchitosanbasedhydrogelspheresforrapidbleedingcontrol
AT zhaoweifeng janusselfpropelledchitosanbasedhydrogelspheresforrapidbleedingcontrol
AT zhaochangsheng janusselfpropelledchitosanbasedhydrogelspheresforrapidbleedingcontrol