Cargando…

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation

In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence of the TCR and whether CAR and TCR mutually cross-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barden, Markus, Holzinger, Astrid, Velas, Lukas, Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György, Schütz, Gerhard J., Hombach, Andreas A., Abken, Hinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929185/ https://www.ncbi.nlm.nih.gov/pubmed/36817444 http://dx.doi.org/10.3389/fimmu.2023.1110482

Ejemplares similares

CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T Cells
por: Mezősi-Csaplár, Marianna, et al.
Publicado: (2023)

Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models
por: Csaplár, Marianna, et al.
Publicado: (2021)

A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts
por: Tóth, Gábor, et al.
Publicado: (2020)

CAR T Cells: A Snapshot on the Growing Options to Design a CAR
por: Holzinger, Astrid, et al.
Publicado: (2019)

CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop
por: Harrer, Dennis Christoph, et al.
Publicado: (2022)

IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors
por: Hombach, Andreas, et al.
Publicado: (2022)

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy
por: Blokon-Kogan, Dayana, et al.
Publicado: (2022)

Most Do, but Some Do Not: CD4(+)CD25(−) T Cells, but Not CD4(+)CD25(+) Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR)
por: Hombach, Andreas A., et al.
Publicado: (2017)

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
por: Thomas, Simone, et al.
Publicado: (2023)

In vitro, in vivo and microscopic analysis of tumor immunotherapy using combination of two antibodies against the same ErbB2 target
por: Toth, Gabor, et al.
Publicado: (2014)

The CD3-Zeta Chimeric Antigen Receptor Overcomes TCR Hypo-Responsiveness of Human Terminal Late-Stage T Cells
por: Rappl, Gunter, et al.
Publicado: (2012)

Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
por: Chmielewski, Markus, et al.
Publicado: (2013)

CAR's made it to the pancreas
por: Chmielewski, Markus, et al.
Publicado: (2012)

Ragweed Subpollen Particles of Respirable Size Activate Human Dendritic Cells
por: Pazmandi, Kitti, et al.
Publicado: (2012)

IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells
por: Hombach, Andreas A., et al.
Publicado: (2020)

The combination of trastuzumab and pertuzumab administered at approved doses may delay development of trastuzumab resistance by additively enhancing antibody-dependent cell-mediated cytotoxicity
por: Tóth, Gábor, et al.
Publicado: (2016)

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer
por: Hombach, Andreas A., et al.
Publicado: (2023)

Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance
por: Kaljanac, Marcell, et al.
Publicado: (2022)

TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
por: Poorebrahim, Mansour, et al.
Publicado: (2021)

Targeting two co-operating cytokines efficiently shapes immune responses
por: Hombach, Andreas A., et al.
Publicado: (2013)

Young T Cells Age During a Redirected Anti-Tumor Attack: Chimeric Antigen Receptor-Provided Dual Costimulation is Half the Battle
por: Hombach, Andreas A., et al.
Publicado: (2013)

Joining Forces for Cancer Treatment: From “TCR versus CAR” to “TCR and CAR”
por: Teppert, Karin, et al.
Publicado: (2022)

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)
por: Cassioli, Chiara, et al.
Publicado: (2022)

Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells
por: Schlimper, Claudia, et al.
Publicado: (2012)

Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However
por: Bristow, Michael R., et al.
Publicado: (2018)

IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities
por: Harrer, Dennis Christoph, et al.
Publicado: (2023)

Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse
por: Kim, Bonah, et al.
Publicado: (2021)

Anti-CD19 CAR T cells potently redirected to kill solid tumor cells
por: Ambrose, Christine, et al.
Publicado: (2021)

Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy
por: Paasch, Daniela, et al.
Publicado: (2022)

Nanobody Based Dual Specific CARs
por: De Munter, Stijn, et al.
Publicado: (2018)

Ecological networks: Pursuing the shortest path, however narrow and crooked
por: Costa, Andrea, et al.
Publicado: (2019)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation
por: Yakovian, Oren, et al.
Publicado: (2018)

An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack
por: Jahn, Tobias, et al.
Publicado: (2012)

CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products
por: Kath, Jonas, et al.
Publicado: (2023)

Engineered T Cells for the Adoptive Therapy of B-Cell Chronic Lymphocytic Leukaemia
por: Koehler, Philipp, et al.
Publicado: (2012)

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells
por: Hombach, Andreas A., et al.
Publicado: (2012)

Polarized release of TCR-enriched microvesicles at the T cell immunological synapse
por: Choudhuri, Kaushik, et al.
Publicado: (2014)

Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision below 15 nm
por: Velas, Lukas, et al.
Publicado: (2021)

The reasons for its effectiveness, however, remain in dispute—A tribute to Irving Kirsch
por: Gaab, Jens
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_819q3m1vh862skku7rnbhuv749