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CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation

In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence of the TCR and whether CAR and TCR mutually cross-...

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Detalles Bibliográficos
Autores principales:	Barden, Markus, Holzinger, Astrid, Velas, Lukas, Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György, Schütz, Gerhard J., Hombach, Andreas A., Abken, Hinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929185/ https://www.ncbi.nlm.nih.gov/pubmed/36817444 http://dx.doi.org/10.3389/fimmu.2023.1110482

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