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Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy
The combination of photothermal therapy with chemotherapy has gradually developed into promising cancer therapy. Here, a synergistic photothermal-chemotherapy nanoplatform based on polydopamine (PDA)-coated gold nanoparticles (AuNPs) were facilely achieved via the in situ polymerization of dopamine...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929200/ https://www.ncbi.nlm.nih.gov/pubmed/36818397 http://dx.doi.org/10.1016/j.ajps.2023.100781 |
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author | Chen, Bo Mei, Lan Fan, Rangrang Chuan, Di Ren, Yangmei Mu, Min Chen, Haifeng Zou, Bingwen Guo, Gang |
author_facet | Chen, Bo Mei, Lan Fan, Rangrang Chuan, Di Ren, Yangmei Mu, Min Chen, Haifeng Zou, Bingwen Guo, Gang |
author_sort | Chen, Bo |
collection | PubMed |
description | The combination of photothermal therapy with chemotherapy has gradually developed into promising cancer therapy. Here, a synergistic photothermal-chemotherapy nanoplatform based on polydopamine (PDA)-coated gold nanoparticles (AuNPs) were facilely achieved via the in situ polymerization of dopamine (DA) on the surface of AuNPs. This nanoplatform exhibited augmented photothermal conversion efficiency and enhanced colloidal stability in comparison with uncoated PDA shell AuNPs. The i-motif DNA nanostructure was assembled on PDA-coated AuNPs, which could be transformed into a C-quadruplex structure under an acidic environment, showing a characteristic pH response. The PDA shell served as a linker between the AuNPs and the i-motif DNA nanostructure. To enhance the specific cellular uptake, the AS1411 aptamer was introduced to the DNA nanostructure employed as a targeting ligand. In addition, Dox-loaded NPs (DAu@PDA-AS141) showed the pH/photothermal-responsive release of Dox. The photothermal effect of DAu@PDA-AS141 elicited excellent photothermal performance and efficient cancer cell inhibition under 808 nm near-infrared (NIR) irradiation. Overall, these results demonstrate that the DAu@PDA-AS141 nanoplatform shows great potential in synergistic photothermal-chemotherapy. |
format | Online Article Text |
id | pubmed-9929200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-99292002023-02-16 Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy Chen, Bo Mei, Lan Fan, Rangrang Chuan, Di Ren, Yangmei Mu, Min Chen, Haifeng Zou, Bingwen Guo, Gang Asian J Pharm Sci Original Research Paper The combination of photothermal therapy with chemotherapy has gradually developed into promising cancer therapy. Here, a synergistic photothermal-chemotherapy nanoplatform based on polydopamine (PDA)-coated gold nanoparticles (AuNPs) were facilely achieved via the in situ polymerization of dopamine (DA) on the surface of AuNPs. This nanoplatform exhibited augmented photothermal conversion efficiency and enhanced colloidal stability in comparison with uncoated PDA shell AuNPs. The i-motif DNA nanostructure was assembled on PDA-coated AuNPs, which could be transformed into a C-quadruplex structure under an acidic environment, showing a characteristic pH response. The PDA shell served as a linker between the AuNPs and the i-motif DNA nanostructure. To enhance the specific cellular uptake, the AS1411 aptamer was introduced to the DNA nanostructure employed as a targeting ligand. In addition, Dox-loaded NPs (DAu@PDA-AS141) showed the pH/photothermal-responsive release of Dox. The photothermal effect of DAu@PDA-AS141 elicited excellent photothermal performance and efficient cancer cell inhibition under 808 nm near-infrared (NIR) irradiation. Overall, these results demonstrate that the DAu@PDA-AS141 nanoplatform shows great potential in synergistic photothermal-chemotherapy. Shenyang Pharmaceutical University 2023-03 2023-02-01 /pmc/articles/PMC9929200/ /pubmed/36818397 http://dx.doi.org/10.1016/j.ajps.2023.100781 Text en © 2023 Shenyang Pharmaceutical University. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Paper Chen, Bo Mei, Lan Fan, Rangrang Chuan, Di Ren, Yangmei Mu, Min Chen, Haifeng Zou, Bingwen Guo, Gang Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title | Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title_full | Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title_fullStr | Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title_full_unstemmed | Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title_short | Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy |
title_sort | polydopamine-coated i-motif dna/gold nanoplatforms for synergistic photothermal-chemotherapy |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929200/ https://www.ncbi.nlm.nih.gov/pubmed/36818397 http://dx.doi.org/10.1016/j.ajps.2023.100781 |
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