Cargando…

MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis

Transcriptome analysis of head and neck squamous cell carcinoma (HNSCC) has been pivotal to comprehending the convoluted biology of HNSCC tumors. MAPKAPK2 or MK2 is a critical modulator of the mRNA turnover of crucial genes involved in HNSCC progression. However, MK2-centric transcriptome profiles o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soni, Sourabh, Anand, Prince, Swarnkar, Mohit Kumar, Patial, Vikram, Tirpude, Narendra V., Padwad, Yogendra S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929207/ https://www.ncbi.nlm.nih.gov/pubmed/36817960 http://dx.doi.org/10.1016/j.csbj.2023.01.039

Ejemplares similares

MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability
por: Soni, Sourabh, et al.
Publicado: (2019)

MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
por: Soni, Sourabh, et al.
Publicado: (2019)

Metagenomic signatures reveal the key role of phloretin in amelioration of gut dysbiosis attributed to metabolic dysfunction-associated fatty liver disease by time-dependent modulation of gut microbiome
por: Chhimwal, Jyoti, et al.
Publicado: (2023)

Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats
por: Kumar, Shiv, et al.
Publicado: (2017)

Pharmaco-immunomodulatory interventions for averting cytokine storm-linked disease severity in SARS-CoV-2 infection
por: Kumar, Arbind, et al.
Publicado: (2022)

Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus
por: Kumar, Arbind, et al.
Publicado: (2022)

Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing
por: Singla, Rubbel, et al.
Publicado: (2017)

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
por: Wei, Yongjie, et al.
Publicado: (2015)

Identification and Functional Analysis of MAPKAPK2 in Hyriopsis cumingii
por: Gu, Yang, et al.
Publicado: (2022)

Hematopoietic neoplasms in Prkar2a-deficient mice
por: Saloustros, Emmanouil, et al.
Publicado: (2015)

A Novel Role for MAPKAPK2 in Morphogenesis during Zebrafish Development
por: Holloway, Beth A., et al.
Publicado: (2009)

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis
por: Ozcan, Lale, et al.
Publicado: (2021)

Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics
por: Darnal, Sanyukta, et al.
Publicado: (2023)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
por: Herranz, Nicolás, et al.
Publicado: (2015)

PRKAR1A and Thyroid Tumors
por: Pitsava, Georgia, et al.
Publicado: (2021)

PRKAR2B plays an oncogenic role in the castration-resistant prostate cancer
por: Sha, Jianjun, et al.
Publicado: (2016)

MUC1 confers radioresistance in head and neck squamous cell carcinoma (HNSCC) cells
por: Huang, Tian-qiao, et al.
Publicado: (2020)

STK25 inhibits PKA signaling by phosphorylating PRKAR1A
por: Zhang, Xiaokan, et al.
Publicado: (2022)

Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation
por: London, Edra, et al.
Publicado: (2020)

MUC1 expression and anti-MUC1 serum immune response in head and neck squamous cell carcinoma (HNSCC): a multivariate analysis
por: Rabassa, Martín E, et al.
Publicado: (2006)

Novel 3-Methyleneisoindolinones Diversified via Intramolecular Heck Cyclization Induce Oxidative Stress, Decrease Mitochondrial Membrane Potential, Disrupt Cell Cycle, and Induce Apoptosis in Head and Neck Squamous Cell Carcinoma Cells
por: Sharma, Arti, et al.
Publicado: (2022)

The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome
por: Davis, Terence, et al.
Publicado: (2013)

MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients
por: Zhong, Zhenggang, et al.
Publicado: (2023)

Novel Mutation in PRKAR1A in Carney Complex
por: Park, Ko Un, et al.
Publicado: (2012)

Retracted: Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling
por: Houslay, K F, et al.
Publicado: (2019)

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors
por: Manchanda, Parmeet K., et al.
Publicado: (2012)

Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
por: Guiot, J., et al.
Publicado: (2016)

MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma
por: Berggren, Kiersten L., et al.
Publicado: (2019)

The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation
por: Moens, Ugo, et al.
Publicado: (2013)

FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus
por: Weise, Stefan C., et al.
Publicado: (2018)

PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
por: Xia, Lei, et al.
Publicado: (2020)

E2F3 promotes liver cancer progression under the regulation of circ-PRKAR1B
por: Liu, Guodong, et al.
Publicado: (2021)

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance
por: Betge, Johannes, et al.
Publicado: (2016)

Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma
por: He, Jian, et al.
Publicado: (2017)

PRKAR1A deficiency impedes hypertrophy and reduces heart size
por: Liu, Yuening, et al.
Publicado: (2020)

Revealing oxidative stress-related genes in osteoporosis and advanced structural biological study for novel natural material discovery regarding MAPKAPK2
por: Zhao, Yingjing, et al.
Publicado: (2022)

SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation
por: Sreekanth, Gopinathan Pillai, et al.
Publicado: (2016)

Regulation of IGFBP-2 expression during fasting
por: Kang, Hye Suk, et al.
Publicado: (2015)

Consolidating the association of biallelic MAPKAPK5 pathogenic variants with a distinct syndromic neurodevelopmental disorder
por: Maroofian, Reza, et al.
Publicado: (2023)

IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults
por: Pettersson-Pablo, Paul, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nc55d85t4qf2psim7j9crkfvrv