Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis

Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is a pore‐forming effector of pyroptosis. In this study, the role of VSMC‐specific GSDMD in the phenotypic alteration of VSMCs...

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Detalles Bibliográficos
Autores principales: Gao, Jianing, Chen, Yanghui, Wang, Huiqing, Li, Xin, Li, Ke, Xu, Yangkai, Xie, Xianwei, Guo, Yansong, Yang, Nana, Zhang, Xinhua, Ma, Dong, Lu, Hong S., Shen, Ying H., Liu, Yong, Zhang, Jifeng, Chen, Y. Eugene, Daugherty, Alan, Wang, Dao Wen, Zheng, Lemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929270/
https://www.ncbi.nlm.nih.gov/pubmed/36567267
http://dx.doi.org/10.1002/advs.202204038

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