Cargando…

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of several target-based screens for activity against Plasmodium falciparum parasites. Together with the known βH crystal structure, the availability of this screening data makes the target amenable to both struct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amod, Leah, Mohunlal, Roxanne, Teixeira, Nicole, Egan, Timothy J., Wicht, Kathryn J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929333/ https://www.ncbi.nlm.nih.gov/pubmed/36788274 http://dx.doi.org/10.1038/s41598-023-29273-w

Ejemplares similares

Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites
por: de Sousa, Ana Carolina C., et al.
Publicado: (2020)

Chloroquine-Resistant Haplotype Plasmodium falciparum Parasites, Haiti
por: Londono, Berlin L., et al.
Publicado: (2009)

Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia
por: Mekonnen, Seleshi Kebede, et al.
Publicado: (2014)

Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance
por: Warhurst, David C., et al.
Publicado: (2016)

The return of chloroquine-susceptible Plasmodium falciparum malaria in Zambia
por: Mwanza, Sydney, et al.
Publicado: (2016)

Correction: Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance
por: Warhurst, David C., et al.
Publicado: (2016)

Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti
por: Neuberger, Ami, et al.
Publicado: (2012)

Sequence-dependent heterochromatin formation in the human malaria parasite Plasmodium falciparum
por: Mori, Toshiyuki, et al.
Publicado: (2023)

On the Mechanism of Chloroquine Resistance in Plasmodium falciparum
por: Chinappi, Mauro, et al.
Publicado: (2010)

Chloroquine-resistant Plasmodium falciparum in Pakistan
por: Khattak, Aamer Ali, et al.
Publicado: (2021)

Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China
por: Lu, Feng, et al.
Publicado: (2017)

Transcriptional variation in the malaria parasite Plasmodium falciparum
por: Rovira-Graells, Núria, et al.
Publicado: (2012)

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea
por: Sekihara, Makoto, et al.
Publicado: (2018)

Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition
por: Ambele, Melvin A, et al.
Publicado: (2012)

Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area
por: Gama, Bianca Ervatti, et al.
Publicado: (2009)

Revisiting the Effect of Pharmaceuticals on Transmission Stage Formation in the Malaria Parasite Plasmodium falciparum
por: Thommen, Basil T., et al.
Publicado: (2022)

Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites
por: Reiling, Sarah J., et al.
Publicado: (2018)

The Plasmodium falciparum chloroquine resistance transporter is associated with the ex vivo P. falciparum African parasite response to pyronaridine
por: Madamet, Marylin, et al.
Publicado: (2016)

Origin of the human malaria parasite Plasmodium falciparum in gorillas
por: Liu, Weimin, et al.
Publicado: (2010)

Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax
Publicado: (1982)

The protein-phosphatome of the human malaria parasite Plasmodium falciparum
por: Wilkes, Jonathan M, et al.
Publicado: (2008)

Alternative Protein Secretion in the Malaria Parasite Plasmodium falciparum
por: Thavayogarajah, Thuvaraka, et al.
Publicado: (2015)

Chloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission to Mosquitoes of Multidrug-Resistant Plasmodium falciparum
por: Hallett, Rachel L, et al.
Publicado: (2006)

Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite's membrane potential
por: Niemand, J, et al.
Publicado: (2010)

Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite's membrane potential
por: Niemand, J, et al.
Publicado: (2010)

Multiplication rate variation in the human malaria parasite Plasmodium falciparum
por: Murray, Lee, et al.
Publicado: (2017)

Targeting NAD(+) Metabolism in the Human Malaria Parasite Plasmodium falciparum
por: O'Hara, Jessica K., et al.
Publicado: (2014)

Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum
por: Ruiz, José Luis, et al.
Publicado: (2018)

Haematinic Deficiency and Macrocytosis in Middle-Aged and Older Adults
por: McNamee, Therese, et al.
Publicado: (2013)

Invasion of mouse erythrocytes by the human malaria parasite, Plasmodium falciparum
Publicado: (1987)

Protease-associated cellular networks in malaria parasite Plasmodium falciparum
por: Lilburn, Timothy G, et al.
Publicado: (2011)

The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum
por: Cervantes, Serena, et al.
Publicado: (2014)

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites
por: Lee, Marcus CS, et al.
Publicado: (2014)

Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
por: Hoeijmakers, Wieteke Anna Maria, et al.
Publicado: (2019)

Immunosuppression in Malaria: Do Plasmodium falciparum Parasites Hijack the Host?
por: Calle, Carlos Lamsfus, et al.
Publicado: (2021)

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites
por: Mathews, Emily S., et al.
Publicado: (2021)

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine
por: Venkatesan, Meera, et al.
Publicado: (2014)

Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria()
por: Cunnington, Aubrey J., et al.
Publicado: (2013)

GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites
por: Jezewski, Andrew J., et al.
Publicado: (2022)

Uptake of a fluorescently tagged chloroquine analogue is reduced in CQ-resistant compared to CQ-sensitive Plasmodium falciparum parasites
por: Reiling, Sarah J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3s405dgib9og63evo96ddphrud