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Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition

Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in...

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Autores principales: Zhou, Mengzhen, Tang, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929354/
https://www.ncbi.nlm.nih.gov/pubmed/36816725
http://dx.doi.org/10.3389/fmed.2022.984227
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author Zhou, Mengzhen
Tang, Shi
author_facet Zhou, Mengzhen
Tang, Shi
author_sort Zhou, Mengzhen
collection PubMed
description Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA.
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spelling pubmed-99293542023-02-16 Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition Zhou, Mengzhen Tang, Shi Front Med (Lausanne) Medicine Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA. Frontiers Media S.A. 2023-02-01 /pmc/articles/PMC9929354/ /pubmed/36816725 http://dx.doi.org/10.3389/fmed.2022.984227 Text en Copyright © 2023 Zhou and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhou, Mengzhen
Tang, Shi
Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title_full Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title_fullStr Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title_full_unstemmed Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title_short Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
title_sort effect of a dual orexin receptor antagonist on alzheimer's disease: sleep disorders and cognition
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929354/
https://www.ncbi.nlm.nih.gov/pubmed/36816725
http://dx.doi.org/10.3389/fmed.2022.984227
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