Cargando…

Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence

BACKGROUND: Histogram analysis of the diffusion-weighted imaging (DWI) parameters is widely used to differentiate the breast lesions. However, histogram analysis of the diffusion-kurtosis imaging (DKI) parameters for the single-shot echo-planar imaging (ss-EPI) and readout-segmented echo planar imag...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Cicheng, Zhan, Chenao, Hu, Yiqi, Yin, Ting, Grimm, Robert, Ai, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929405/
https://www.ncbi.nlm.nih.gov/pubmed/36819265
http://dx.doi.org/10.21037/qims-22-475
_version_ 1784888847347220480
author Huang, Cicheng
Zhan, Chenao
Hu, Yiqi
Yin, Ting
Grimm, Robert
Ai, Tao
author_facet Huang, Cicheng
Zhan, Chenao
Hu, Yiqi
Yin, Ting
Grimm, Robert
Ai, Tao
author_sort Huang, Cicheng
collection PubMed
description BACKGROUND: Histogram analysis of the diffusion-weighted imaging (DWI) parameters is widely used to differentiate the breast lesions. However, histogram analysis of the diffusion-kurtosis imaging (DKI) parameters for the single-shot echo-planar imaging (ss-EPI) and readout-segmented echo planar imaging (rs-EPI) sequences has not been compared in breast cancer. Thus, this study is to investigate the diagnostic accuracy and reliability of the histogram parameters derived from the rs-EPI and ss-EPI sequences of DKI parameters in distinguishing between the benign and malignant breast lesions. METHODS: This single-center, retrospective cohort study enrolled 205 consecutive patients with breast lesions (65 benign and 140 malignant). The patients underwent breast magnetic resonance imaging (MRI) with a 3T scanner using the rs-EPI and ss-EPI sequences with 4 b values (0, 50, 1,000, and 2,000 s/mm(2)). The regions of interest (ROIs) were manually delineated for all the lesion images from both the sequences, and the histogram parameters were extracted from the apparent diffusion coefficient (ADC) and apparent diffusional kurtosis (K(app)) maps. Statistical analysis was performed using the Kolmogorov-Smirnov test, the student’s t-test, and the receiver operating characteristic (ROC) curves. RESULTS: The mean, 25th, 50th, 75th, and 100th percentiles, skewness, and kurtosis values derived from apparent diffusion for non-Gaussian distribution (D(app)) and K(app) maps showed good or excellent intra-observer agreement (ICC: 0.695 to 0.863).The mean and the 25th, 50th, 75th, and 100th percentile values for D(app) were significantly lower and the mean and the 25th, 50th, 75th, and 100th percentile values for K(app) were significantly higher in the malignant breast lesions compared with those in the benign breast lesions for both the rs-EPI and ss-EPI sequences (all P<0.05). The majority of the histogram K(app) and D(app) parameters (except skewness and kurtosis) for the benign and malignant lesions showed significant differences between the ss-EPI and the rs-EPI sequences (P<0.05). ROC curve analysis showed that the AUC values for the 75th percentile of K(app) (0.854 for rs-EPI, 0.844 for ss-EPI) and the 25th percentile of D(app) (0.866 for rs-EPI, 0.858 for ss-EPI) were highest for both DKI sequences. The diagnostic performance of the rs-EPI sequence was better than the ss-EPI sequence for all the histogram parameters except the skewness value of D(app). CONCLUSIONS: Histogram parameters from the rs-EPI sequence were more reliable and accurate in differentiating malignant and benign breast lesions than those from the ss-EPI sequence.
format Online
Article
Text
id pubmed-9929405
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-99294052023-02-16 Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence Huang, Cicheng Zhan, Chenao Hu, Yiqi Yin, Ting Grimm, Robert Ai, Tao Quant Imaging Med Surg Original Article BACKGROUND: Histogram analysis of the diffusion-weighted imaging (DWI) parameters is widely used to differentiate the breast lesions. However, histogram analysis of the diffusion-kurtosis imaging (DKI) parameters for the single-shot echo-planar imaging (ss-EPI) and readout-segmented echo planar imaging (rs-EPI) sequences has not been compared in breast cancer. Thus, this study is to investigate the diagnostic accuracy and reliability of the histogram parameters derived from the rs-EPI and ss-EPI sequences of DKI parameters in distinguishing between the benign and malignant breast lesions. METHODS: This single-center, retrospective cohort study enrolled 205 consecutive patients with breast lesions (65 benign and 140 malignant). The patients underwent breast magnetic resonance imaging (MRI) with a 3T scanner using the rs-EPI and ss-EPI sequences with 4 b values (0, 50, 1,000, and 2,000 s/mm(2)). The regions of interest (ROIs) were manually delineated for all the lesion images from both the sequences, and the histogram parameters were extracted from the apparent diffusion coefficient (ADC) and apparent diffusional kurtosis (K(app)) maps. Statistical analysis was performed using the Kolmogorov-Smirnov test, the student’s t-test, and the receiver operating characteristic (ROC) curves. RESULTS: The mean, 25th, 50th, 75th, and 100th percentiles, skewness, and kurtosis values derived from apparent diffusion for non-Gaussian distribution (D(app)) and K(app) maps showed good or excellent intra-observer agreement (ICC: 0.695 to 0.863).The mean and the 25th, 50th, 75th, and 100th percentile values for D(app) were significantly lower and the mean and the 25th, 50th, 75th, and 100th percentile values for K(app) were significantly higher in the malignant breast lesions compared with those in the benign breast lesions for both the rs-EPI and ss-EPI sequences (all P<0.05). The majority of the histogram K(app) and D(app) parameters (except skewness and kurtosis) for the benign and malignant lesions showed significant differences between the ss-EPI and the rs-EPI sequences (P<0.05). ROC curve analysis showed that the AUC values for the 75th percentile of K(app) (0.854 for rs-EPI, 0.844 for ss-EPI) and the 25th percentile of D(app) (0.866 for rs-EPI, 0.858 for ss-EPI) were highest for both DKI sequences. The diagnostic performance of the rs-EPI sequence was better than the ss-EPI sequence for all the histogram parameters except the skewness value of D(app). CONCLUSIONS: Histogram parameters from the rs-EPI sequence were more reliable and accurate in differentiating malignant and benign breast lesions than those from the ss-EPI sequence. AME Publishing Company 2023-01-02 2023-02-01 /pmc/articles/PMC9929405/ /pubmed/36819265 http://dx.doi.org/10.21037/qims-22-475 Text en 2023 Quantitative Imaging in Medicine and Surgery. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Huang, Cicheng
Zhan, Chenao
Hu, Yiqi
Yin, Ting
Grimm, Robert
Ai, Tao
Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title_full Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title_fullStr Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title_full_unstemmed Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title_short Histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
title_sort histogram analysis of breast diffusion kurtosis imaging: a comparison between readout-segmented and single-shot echo-planar imaging sequence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929405/
https://www.ncbi.nlm.nih.gov/pubmed/36819265
http://dx.doi.org/10.21037/qims-22-475
work_keys_str_mv AT huangcicheng histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence
AT zhanchenao histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence
AT huyiqi histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence
AT yinting histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence
AT grimmrobert histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence
AT aitao histogramanalysisofbreastdiffusionkurtosisimagingacomparisonbetweenreadoutsegmentedandsingleshotechoplanarimagingsequence