Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition

Bone morphogenetic proteins (BMPs) are secreted cytokines belonging to the transforming growth factor-β superfamily. New therapeutic approaches based on BMP activity, particularly for cartilage and bone repair, have sparked considerable interest; however, a lack of understanding of their interaction...

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Detalles Bibliográficos
Autores principales: Robert, Charly, Kerff, Frédéric, Bouillenne, Fabrice, Gavage, Maxime, Vandevenne, Marylène, Filée, Patrice, Matagne, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929448/
https://www.ncbi.nlm.nih.gov/pubmed/36642181
http://dx.doi.org/10.1016/j.jbc.2023.102892

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