Aptamer-programmable adeno-associated viral vectors as a novel platform for cell-specific gene transfer

Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue. Here, we developed new chemically modified AAV vectors (Nε-AAVs) displaying a single site substit...

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Detalles Bibliográficos
Autores principales: Puzzo, Francesco, Zhang, Chuanling, Powell Gray, Bethany, Zhang, Feijie, Sullenger, Bruce A., Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929486/
https://www.ncbi.nlm.nih.gov/pubmed/36817723
http://dx.doi.org/10.1016/j.omtn.2023.01.007

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