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Surf4, cargo trafficking, lipid metabolism, and therapeutic implications

Surfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic reticulum (ER) membrane. It is ubiquitously expressed and functions as a cargo receptor, mediating cargo transport from the ER to the Golgi apparatus via the canonical coat protein complex II (COPII)-coated vesi...

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Autores principales: Shen, Yishi, Gu, Hong-Mei, Qin, Shucun, Zhang, Da-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929512/
https://www.ncbi.nlm.nih.gov/pubmed/36574593
http://dx.doi.org/10.1093/jmcb/mjac063
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author Shen, Yishi
Gu, Hong-Mei
Qin, Shucun
Zhang, Da-Wei
author_facet Shen, Yishi
Gu, Hong-Mei
Qin, Shucun
Zhang, Da-Wei
author_sort Shen, Yishi
collection PubMed
description Surfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic reticulum (ER) membrane. It is ubiquitously expressed and functions as a cargo receptor, mediating cargo transport from the ER to the Golgi apparatus via the canonical coat protein complex II (COPII)-coated vesicles or specific vesicles. It also participates in ER–Golgi protein trafficking through a tubular network. Meanwhile, it facilitates retrograde transportation of cargos from the Golgi apparatus to the ER through COPI-coated vesicles. Surf4 can selectively mediate export of diverse cargos, such as PCSK9 very low-density lipoprotein (VLDL), progranulin, α1-antitrypsin, STING, proinsulin, and erythropoietin. It has been implicated in facilitating VLDL secretion, promoting cell proliferation and migration, and increasing replication of positive-strand RNA viruses. Therefore, Surf4 plays a crucial role in various physiological and pathophysiological processes and emerges as a promising therapeutic target. However, the molecular mechanisms by which Surf4 selectively sorts diverse cargos for ER–Golgi protein trafficking remain elusive. Here, we summarize the most recent advances in Surf4, focusing on its role in lipid metabolism.
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spelling pubmed-99295122023-02-16 Surf4, cargo trafficking, lipid metabolism, and therapeutic implications Shen, Yishi Gu, Hong-Mei Qin, Shucun Zhang, Da-Wei J Mol Cell Biol Review Surfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic reticulum (ER) membrane. It is ubiquitously expressed and functions as a cargo receptor, mediating cargo transport from the ER to the Golgi apparatus via the canonical coat protein complex II (COPII)-coated vesicles or specific vesicles. It also participates in ER–Golgi protein trafficking through a tubular network. Meanwhile, it facilitates retrograde transportation of cargos from the Golgi apparatus to the ER through COPI-coated vesicles. Surf4 can selectively mediate export of diverse cargos, such as PCSK9 very low-density lipoprotein (VLDL), progranulin, α1-antitrypsin, STING, proinsulin, and erythropoietin. It has been implicated in facilitating VLDL secretion, promoting cell proliferation and migration, and increasing replication of positive-strand RNA viruses. Therefore, Surf4 plays a crucial role in various physiological and pathophysiological processes and emerges as a promising therapeutic target. However, the molecular mechanisms by which Surf4 selectively sorts diverse cargos for ER–Golgi protein trafficking remain elusive. Here, we summarize the most recent advances in Surf4, focusing on its role in lipid metabolism. Oxford University Press 2022-11-29 /pmc/articles/PMC9929512/ /pubmed/36574593 http://dx.doi.org/10.1093/jmcb/mjac063 Text en © The Author(s) (2022). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Shen, Yishi
Gu, Hong-Mei
Qin, Shucun
Zhang, Da-Wei
Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title_full Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title_fullStr Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title_full_unstemmed Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title_short Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
title_sort surf4, cargo trafficking, lipid metabolism, and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929512/
https://www.ncbi.nlm.nih.gov/pubmed/36574593
http://dx.doi.org/10.1093/jmcb/mjac063
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