Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

Here we extend the understanding of how chemical inhibition of SHIP paralogs controls obesity. We compare different classes of SHIP inhibitors and find that selective inhibitors of SHIP1 or SHIP2 are unable to prevent weight gain and body fat accumulation during increased caloric intake. Surprisingl...

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Detalles Bibliográficos
Autores principales: Fernandes, Sandra, Srivastava, Neetu, Pedicone, Chiara, Sudan, Raki, Luke, Elizabeth A., Dungan, Otto M., Pacherille, Angela, Meyer, Shea T., Dormann, Shawn, Schurmans, Stéphane, Chambers, Benedict J., Chisholm, John D., Kerr, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929608/
https://www.ncbi.nlm.nih.gov/pubmed/36818285
http://dx.doi.org/10.1016/j.isci.2023.106071

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