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Recognition of the CCT5 di‐Glu degron by CRL4(DCAF12) is dependent on TRiC assembly
Assembly Quality Control (AQC) E3 ubiquitin ligases target incomplete or incorrectly assembled protein complexes for degradation. The CUL4‐RBX1‐DDB1‐DCAF12 (CRL4(DCAF12)) E3 ligase preferentially ubiquitinates proteins that carry a C‐terminal double glutamate (di‐Glu) motif. Reported CRL4(DCAF12) di...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929631/ https://www.ncbi.nlm.nih.gov/pubmed/36715408 http://dx.doi.org/10.15252/embj.2022112253 |