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Recognition of the CCT5 di‐Glu degron by CRL4(DCAF12) is dependent on TRiC assembly

Assembly Quality Control (AQC) E3 ubiquitin ligases target incomplete or incorrectly assembled protein complexes for degradation. The CUL4‐RBX1‐DDB1‐DCAF12 (CRL4(DCAF12)) E3 ligase preferentially ubiquitinates proteins that carry a C‐terminal double glutamate (di‐Glu) motif. Reported CRL4(DCAF12) di...

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Detalles Bibliográficos
Autores principales: Pla‐Prats, Carlos, Cavadini, Simone, Kempf, Georg, Thomä, Nicolas H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929631/
https://www.ncbi.nlm.nih.gov/pubmed/36715408
http://dx.doi.org/10.15252/embj.2022112253

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