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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity

Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body. Glucocorticoid receptors can bind to response elements throughout the genome to elicit changes in transcription, an adaptation observed a...

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Detalles Bibliográficos
Autores principales: Bartlett, Andrew A., Guffanti, Guia, Hunter, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929632/
https://www.ncbi.nlm.nih.gov/pubmed/36816533
http://dx.doi.org/10.1016/j.ynstr.2023.100522
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author Bartlett, Andrew A.
Guffanti, Guia
Hunter, Richard G.
author_facet Bartlett, Andrew A.
Guffanti, Guia
Hunter, Richard G.
author_sort Bartlett, Andrew A.
collection PubMed
description Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body. Glucocorticoid receptors can bind to response elements throughout the genome to elicit changes in transcription, an adaptation observed at the cellular level. Yet, the transcriptional changes as a consequence of glucocorticoid receptor activation are variable across brain regions, stress conditions and recurrent bouts of glucocorticoid exposure. Here we describe a non-coding RNA, B2 SINE, which is regulated by glucocorticoids and can in turn regulate glucocorticoid receptor transcriptional activity. We show that activated glucocorticoid receptors interact directly with B2 SINE RNA via a decoy response element contained within the transcript sequence and alter receptor binding to response elements in the genome and, subsequently, changes in loci expression.
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spelling pubmed-99296322023-02-16 B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity Bartlett, Andrew A. Guffanti, Guia Hunter, Richard G. Neurobiol Stress Original Research Article Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body. Glucocorticoid receptors can bind to response elements throughout the genome to elicit changes in transcription, an adaptation observed at the cellular level. Yet, the transcriptional changes as a consequence of glucocorticoid receptor activation are variable across brain regions, stress conditions and recurrent bouts of glucocorticoid exposure. Here we describe a non-coding RNA, B2 SINE, which is regulated by glucocorticoids and can in turn regulate glucocorticoid receptor transcriptional activity. We show that activated glucocorticoid receptors interact directly with B2 SINE RNA via a decoy response element contained within the transcript sequence and alter receptor binding to response elements in the genome and, subsequently, changes in loci expression. Elsevier 2023-02-01 /pmc/articles/PMC9929632/ /pubmed/36816533 http://dx.doi.org/10.1016/j.ynstr.2023.100522 Text en © 2023 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Bartlett, Andrew A.
Guffanti, Guia
Hunter, Richard G.
B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title_full B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title_fullStr B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title_full_unstemmed B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title_short B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
title_sort b2 sine rna as a novel regulator of glucocorticoid receptor transcriptional activity
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929632/
https://www.ncbi.nlm.nih.gov/pubmed/36816533
http://dx.doi.org/10.1016/j.ynstr.2023.100522
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