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IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer

Drug resistance contributes to poor therapeutic response in urothelial carcinoma (UC). Metabolomic analysis suggested metabolic reprogramming in gemcitabine‐resistant urothelial carcinoma cells, whereby increased aerobic glycolysis and metabolic stimulation of the pentose phosphate pathway (PPP) pro...

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Detalles Bibliográficos
Autores principales:	Shigeta, Keisuke, Hasegawa, Masanori, Hishiki, Takako, Naito, Yoshiko, Baba, Yuto, Mikami, Shuji, Matsumoto, Kazuhiro, Mizuno, Ryuichi, Miyajima, Akira, Kikuchi, Eiji, Saya, Hideyuki, Kosaka, Takeo, Oya, Mototsugu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929641/ https://www.ncbi.nlm.nih.gov/pubmed/36637036 http://dx.doi.org/10.15252/embj.2022110620

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