Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

Synaptic dysfunction caused by soluble β‐amyloid peptide (Aβ) is a hallmark of early‐stage Alzheimer's disease (AD), and is tightly linked to cognitive decline. By yet unknown mechanisms, Aβ suppresses the transcriptional activity of cAMP‐responsive element‐binding protein (CREB), a master regu...

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Detalles Bibliográficos
Autores principales: Grochowska, Katarzyna M, Gomes, Guilherme M, Raman, Rajeev, Kaushik, Rahul, Sosulina, Liudmila, Kaneko, Hiroshi, Oelschlegel, Anja M, Yuanxiang, PingAn, Reyes‐Resina, Irene, Bayraktar, Gonca, Samer, Sebastian, Spilker, Christina, Woo, Marcel S, Morawski, Markus, Goldschmidt, Jürgen, Friese, Manuel A, Rossner, Steffen, Navarro, Gemma, Remy, Stefan, Reissner, Carsten, Karpova, Anna, Kreutz, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929644/
https://www.ncbi.nlm.nih.gov/pubmed/36594364
http://dx.doi.org/10.15252/embj.2022112453

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