Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report

Hidradenitis suppurativa (HS) is an inflammatory skin disease showing a chronic-remitting course. It has been rarely reported that long-term inflammation in HS could lead to serious complications like cutaneous squamous cell carcinoma. Cemiplimab is a fully human antibody immunotherapy that inhibits...

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Autores principales: Ruggiero, Angelo, Lauro, Wanda, Miano, Chiara, Villani, Alessia, Fabbrocini, Gabriella, Marasca, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929653/
https://www.ncbi.nlm.nih.gov/pubmed/36817850
http://dx.doi.org/10.1159/000525347
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author Ruggiero, Angelo
Lauro, Wanda
Miano, Chiara
Villani, Alessia
Fabbrocini, Gabriella
Marasca, Claudio
author_facet Ruggiero, Angelo
Lauro, Wanda
Miano, Chiara
Villani, Alessia
Fabbrocini, Gabriella
Marasca, Claudio
author_sort Ruggiero, Angelo
collection PubMed
description Hidradenitis suppurativa (HS) is an inflammatory skin disease showing a chronic-remitting course. It has been rarely reported that long-term inflammation in HS could lead to serious complications like cutaneous squamous cell carcinoma. Cemiplimab is a fully human antibody immunotherapy that inhibits programmed cell death protein-1, approved for the treatment of locally advanced squamous cell carcinoma, or metastatic squamous cell carcinoma, in patients not eligible for curative surgery or radiotherapy. Herein, we report the case of a 56-year-old patient developing an invasive SCC on longstanding and unresponsive HS lesions successfully treated with cemiplimab.
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spelling pubmed-99296532023-02-16 Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report Ruggiero, Angelo Lauro, Wanda Miano, Chiara Villani, Alessia Fabbrocini, Gabriella Marasca, Claudio Case Rep Dermatol Single Case Hidradenitis suppurativa (HS) is an inflammatory skin disease showing a chronic-remitting course. It has been rarely reported that long-term inflammation in HS could lead to serious complications like cutaneous squamous cell carcinoma. Cemiplimab is a fully human antibody immunotherapy that inhibits programmed cell death protein-1, approved for the treatment of locally advanced squamous cell carcinoma, or metastatic squamous cell carcinoma, in patients not eligible for curative surgery or radiotherapy. Herein, we report the case of a 56-year-old patient developing an invasive SCC on longstanding and unresponsive HS lesions successfully treated with cemiplimab. S. Karger AG 2023-02-14 /pmc/articles/PMC9929653/ /pubmed/36817850 http://dx.doi.org/10.1159/000525347 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Ruggiero, Angelo
Lauro, Wanda
Miano, Chiara
Villani, Alessia
Fabbrocini, Gabriella
Marasca, Claudio
Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title_full Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title_fullStr Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title_full_unstemmed Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title_short Advanced Squamous Cell Carcinoma Developed on Chronic Hidradenitis Suppurativa, Successfully Treated with Cemiplimab: A Case Report
title_sort advanced squamous cell carcinoma developed on chronic hidradenitis suppurativa, successfully treated with cemiplimab: a case report
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929653/
https://www.ncbi.nlm.nih.gov/pubmed/36817850
http://dx.doi.org/10.1159/000525347
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