Stopping the fat: Repurposing an antidepressant for cancer treatment

In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fa...

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Detalles Bibliográficos
Autores principales: Bhullar, Deepika, Commisso, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929654/
https://www.ncbi.nlm.nih.gov/pubmed/36729077
http://dx.doi.org/10.1084/jem.20222097
Descripción
Sumario:In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.

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