Stopping the fat: Repurposing an antidepressant for cancer treatment

In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fa...

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Detalles Bibliográficos
Autores principales: Bhullar, Deepika, Commisso, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929654/
https://www.ncbi.nlm.nih.gov/pubmed/36729077
http://dx.doi.org/10.1084/jem.20222097
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author Bhullar, Deepika
Commisso, Cosimo
author_facet Bhullar, Deepika
Commisso, Cosimo
author_sort Bhullar, Deepika
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description In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.
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spelling pubmed-99296542023-08-02 Stopping the fat: Repurposing an antidepressant for cancer treatment Bhullar, Deepika Commisso, Cosimo J Exp Med Insights In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression. Rockefeller University Press 2023-02-02 /pmc/articles/PMC9929654/ /pubmed/36729077 http://dx.doi.org/10.1084/jem.20222097 Text en © 2023 Bhullar and Commisso https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Bhullar, Deepika
Commisso, Cosimo
Stopping the fat: Repurposing an antidepressant for cancer treatment
title Stopping the fat: Repurposing an antidepressant for cancer treatment
title_full Stopping the fat: Repurposing an antidepressant for cancer treatment
title_fullStr Stopping the fat: Repurposing an antidepressant for cancer treatment
title_full_unstemmed Stopping the fat: Repurposing an antidepressant for cancer treatment
title_short Stopping the fat: Repurposing an antidepressant for cancer treatment
title_sort stopping the fat: repurposing an antidepressant for cancer treatment
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929654/
https://www.ncbi.nlm.nih.gov/pubmed/36729077
http://dx.doi.org/10.1084/jem.20222097
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