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Stopping the fat: Repurposing an antidepressant for cancer treatment
In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929654/ https://www.ncbi.nlm.nih.gov/pubmed/36729077 http://dx.doi.org/10.1084/jem.20222097 |