Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies

Adult-onset immunodeficiency due to interferon-γ-neutralizing autoantibodies (nIFNγ-autoAbs) can remain underdiagnosed. We present a case of severe Mycobacterium colombiense infection with nIFNγ-autoAbs. To ensure early diagnosis, clinicians should have a high index of suspicion in patients of Asian...

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Autores principales: Matono, Takashi, Suzuki, Shotaro, Yamate, Ryosuke, Nakamura, Kenichi, Sakagami, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929714/
https://www.ncbi.nlm.nih.gov/pubmed/36817743
http://dx.doi.org/10.1093/ofid/ofad035
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author Matono, Takashi
Suzuki, Shotaro
Yamate, Ryosuke
Nakamura, Kenichi
Sakagami, Takuro
author_facet Matono, Takashi
Suzuki, Shotaro
Yamate, Ryosuke
Nakamura, Kenichi
Sakagami, Takuro
author_sort Matono, Takashi
collection PubMed
description Adult-onset immunodeficiency due to interferon-γ-neutralizing autoantibodies (nIFNγ-autoAbs) can remain underdiagnosed. We present a case of severe Mycobacterium colombiense infection with nIFNγ-autoAbs. To ensure early diagnosis, clinicians should have a high index of suspicion in patients of Asian descent with opportunistic infections and perform QuantiFERON-TB assay for disease screening.
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spelling pubmed-99297142023-02-16 Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies Matono, Takashi Suzuki, Shotaro Yamate, Ryosuke Nakamura, Kenichi Sakagami, Takuro Open Forum Infect Dis Brief Report Adult-onset immunodeficiency due to interferon-γ-neutralizing autoantibodies (nIFNγ-autoAbs) can remain underdiagnosed. We present a case of severe Mycobacterium colombiense infection with nIFNγ-autoAbs. To ensure early diagnosis, clinicians should have a high index of suspicion in patients of Asian descent with opportunistic infections and perform QuantiFERON-TB assay for disease screening. Oxford University Press 2023-01-27 /pmc/articles/PMC9929714/ /pubmed/36817743 http://dx.doi.org/10.1093/ofid/ofad035 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Matono, Takashi
Suzuki, Shotaro
Yamate, Ryosuke
Nakamura, Kenichi
Sakagami, Takuro
Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title_full Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title_fullStr Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title_full_unstemmed Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title_short Diagnostic and Therapeutic Challenges in Disseminated Mycobacterium colombiense Infection Caused by Interferon-γ Neutralizing Autoantibodies
title_sort diagnostic and therapeutic challenges in disseminated mycobacterium colombiense infection caused by interferon-γ neutralizing autoantibodies
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929714/
https://www.ncbi.nlm.nih.gov/pubmed/36817743
http://dx.doi.org/10.1093/ofid/ofad035
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