Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers

BACKGROUND: Oxidative stress leads to an increase in reactive oxygen in the body. During heart failure (HF), when the body’s antioxidant defense system fails to remove excessive reactive oxygen species, myocardial cells will be damaged or even die. Over the past ten years, the number of research publications on oxidative stress related to HF has increased. METHODS: We searched publications published in 2012–2021 and the Web of Science Core Collection (WoSCC) recording information. Based on the VOSviewer and CiteSpace, we conducted a bibliometric analysis of the overall distribution of journals, keywords, authors, major countries, annual output, active institutions, and cocited literature. The Global Citation Score (GCS) was used to evaluate the impact and quality of highly cited papers. RESULTS: We retrieved 5,616 articles and reviews. Over the past ten years, the number of annual publications on oxidative stress related to HF has increased. USA has published the largest number of articles and obtained the highest number of citations (NC) and H-index. The University of California and PLoS One are the most productive affiliations and journals in terms of publications on oxidative stress related to HF. The GCS of articles written by Paulus WJ in 2013 was 1,632, which was the top ranking. The most frequent keywords are “oxidative stress”, “heart failure”, “inflammation”, “dysfunction” and “apoptosis”. The top three authors are Kang Yuming, Ren Jun and Okoshi Katashi. “Impact“, “induced myocardial infarction”, “cardiovascular outcome”, “empagliflozin”, “sglt2 inhibitor”, “protect”, and “Na(+)/H(+) exchanger” have become popular research topics. CONCLUSIONS: Our research shows the research focus and development trends of oxidative stress related to HF in the past decade. Understanding the most important indicators of oxidative stress related to HF and the hot spots in the field of oxidative stress research related to HF can assist scholars, countries and policy-makers in the field in better understanding oxidative stress related to HF and can also lead to better decisions in oxidative stress treatment.