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Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders
Individuals with history of childhood trauma are characterized by aberrant resting-state limbic and paralimbic functional network connectivity. However, it is unclear whether specific subtypes of trauma (i.e., experienced vs observed or community) showcase differential effects. This study examined w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929859/ https://www.ncbi.nlm.nih.gov/pubmed/36764058 http://dx.doi.org/10.1016/j.nicl.2023.103343 |
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author | Allen, Corey H. Shold, Jenna Michael Maurer, J. Reynolds, Brooke L. Anderson, Nathaniel E. Harenski, Carla L. Harenski, Keith A. Calhoun, Vince D. Kiehl, Kent A. |
author_facet | Allen, Corey H. Shold, Jenna Michael Maurer, J. Reynolds, Brooke L. Anderson, Nathaniel E. Harenski, Carla L. Harenski, Keith A. Calhoun, Vince D. Kiehl, Kent A. |
author_sort | Allen, Corey H. |
collection | PubMed |
description | Individuals with history of childhood trauma are characterized by aberrant resting-state limbic and paralimbic functional network connectivity. However, it is unclear whether specific subtypes of trauma (i.e., experienced vs observed or community) showcase differential effects. This study examined whether subtypes of childhood trauma (assessed via the Trauma Checklist [TCL] 2.0) were associated with aberrant intra-network amplitude of fluctuations and connectivity (i.e., functional coherence within a network), and inter-network connectivity across resting-state networks among incarcerated juvenile males (n = 179). Subtypes of trauma were established via principal component analysis of the TCL 2.0 and resting-state networks were identified by applying group independent component analysis to resting-state fMRI scans. We tested the association of subtypes of childhood trauma (i.e., TCL Factor 1 measuring experienced trauma and TCL Factor 2 assessing community trauma), and TCL Total scores to the aforementioned functional connectivity measures. TCL Factor 2 scores were associated with increased high-frequency fluctuations and increased intra-network connectivity in cognitive control, auditory, and sensorimotor networks, occurring primarily in paralimbic regions. TCL Total scores exhibited similar neurobiological patterns to TCL Factor 2 scores (with the addition of aberrant intra-network connectivity in visual networks), and no significant associations were found for TCL Factor 1. Consistent with previous analyses of community samples, our results suggest that childhood trauma among incarcerated juvenile males is associated with aberrant intra-network amplitude of fluctuations and connectivity across multiple networks including predominately paralimbic regions. Our results highlight the importance of accounting for traumatic loss, observed trauma, and community trauma in assessing neurobiological aberrances associated with adverse experiences in childhood, as well as the value of trained-rater trauma assessments compared to self-report. |
format | Online Article Text |
id | pubmed-9929859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99298592023-02-16 Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders Allen, Corey H. Shold, Jenna Michael Maurer, J. Reynolds, Brooke L. Anderson, Nathaniel E. Harenski, Carla L. Harenski, Keith A. Calhoun, Vince D. Kiehl, Kent A. Neuroimage Clin Regular Article Individuals with history of childhood trauma are characterized by aberrant resting-state limbic and paralimbic functional network connectivity. However, it is unclear whether specific subtypes of trauma (i.e., experienced vs observed or community) showcase differential effects. This study examined whether subtypes of childhood trauma (assessed via the Trauma Checklist [TCL] 2.0) were associated with aberrant intra-network amplitude of fluctuations and connectivity (i.e., functional coherence within a network), and inter-network connectivity across resting-state networks among incarcerated juvenile males (n = 179). Subtypes of trauma were established via principal component analysis of the TCL 2.0 and resting-state networks were identified by applying group independent component analysis to resting-state fMRI scans. We tested the association of subtypes of childhood trauma (i.e., TCL Factor 1 measuring experienced trauma and TCL Factor 2 assessing community trauma), and TCL Total scores to the aforementioned functional connectivity measures. TCL Factor 2 scores were associated with increased high-frequency fluctuations and increased intra-network connectivity in cognitive control, auditory, and sensorimotor networks, occurring primarily in paralimbic regions. TCL Total scores exhibited similar neurobiological patterns to TCL Factor 2 scores (with the addition of aberrant intra-network connectivity in visual networks), and no significant associations were found for TCL Factor 1. Consistent with previous analyses of community samples, our results suggest that childhood trauma among incarcerated juvenile males is associated with aberrant intra-network amplitude of fluctuations and connectivity across multiple networks including predominately paralimbic regions. Our results highlight the importance of accounting for traumatic loss, observed trauma, and community trauma in assessing neurobiological aberrances associated with adverse experiences in childhood, as well as the value of trained-rater trauma assessments compared to self-report. Elsevier 2023-02-07 /pmc/articles/PMC9929859/ /pubmed/36764058 http://dx.doi.org/10.1016/j.nicl.2023.103343 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Allen, Corey H. Shold, Jenna Michael Maurer, J. Reynolds, Brooke L. Anderson, Nathaniel E. Harenski, Carla L. Harenski, Keith A. Calhoun, Vince D. Kiehl, Kent A. Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title | Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title_full | Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title_fullStr | Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title_full_unstemmed | Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title_short | Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
title_sort | aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929859/ https://www.ncbi.nlm.nih.gov/pubmed/36764058 http://dx.doi.org/10.1016/j.nicl.2023.103343 |
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