Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central...

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Detalles Bibliográficos
Autores principales: Alva, Elizabeth, Rubens, Jeffrey, Chi, Susan, Rosenberg, Tom, Reddy, Alyssa, Raabe, Eric H., Margol, Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929860/
https://www.ncbi.nlm.nih.gov/pubmed/36773516
http://dx.doi.org/10.1016/j.neo.2023.100880
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author Alva, Elizabeth
Rubens, Jeffrey
Chi, Susan
Rosenberg, Tom
Reddy, Alyssa
Raabe, Eric H.
Margol, Ashley
author_facet Alva, Elizabeth
Rubens, Jeffrey
Chi, Susan
Rosenberg, Tom
Reddy, Alyssa
Raabe, Eric H.
Margol, Ashley
author_sort Alva, Elizabeth
collection PubMed
description Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.
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spelling pubmed-99298602023-02-16 Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor Alva, Elizabeth Rubens, Jeffrey Chi, Susan Rosenberg, Tom Reddy, Alyssa Raabe, Eric H. Margol, Ashley Neoplasia Original article Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer. Neoplasia Press 2023-02-09 /pmc/articles/PMC9929860/ /pubmed/36773516 http://dx.doi.org/10.1016/j.neo.2023.100880 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Alva, Elizabeth
Rubens, Jeffrey
Chi, Susan
Rosenberg, Tom
Reddy, Alyssa
Raabe, Eric H.
Margol, Ashley
Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title_full Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title_fullStr Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title_full_unstemmed Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title_short Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
title_sort recent progress and novel approaches to treating atypical teratoid rhabdoid tumor
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929860/
https://www.ncbi.nlm.nih.gov/pubmed/36773516
http://dx.doi.org/10.1016/j.neo.2023.100880
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