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A free boundary problem-in time-for the spread of Covid-19

In this paper we deal with two aspects of the Covid epidemic. The first is a phase change during the epidemic. The empirical observation is that once a certain threshold of active infections is reached, the rate of infection is increasing significantly. This threshold depends, among others, also on...

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Autores principales: Luckhaus, Stephan, Stevens, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930038/
https://www.ncbi.nlm.nih.gov/pubmed/36790624
http://dx.doi.org/10.1007/s00285-023-01881-0
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author Luckhaus, Stephan
Stevens, Angela
author_facet Luckhaus, Stephan
Stevens, Angela
author_sort Luckhaus, Stephan
collection PubMed
description In this paper we deal with two aspects of the Covid epidemic. The first is a phase change during the epidemic. The empirical observation is that once a certain threshold of active infections is reached, the rate of infection is increasing significantly. This threshold depends, among others, also on the season. We model this phenomenon as a jump in the coefficient of the virus exposition, giving the force of infection. In a chemical mass action law this coefficient corresponds to the reaction rate. We get a free boundary problem in time, which exhibits deterministic ‘metastability’. In a population which is in a state of herd immunity, still, if the number of imported infections is large enough, an epidemic wave can start. The second aspect is the two scale nature of the infection network. On one hand side, there is always a finite number of reoccuring–deterministic–contacts, and on the other hand there is a large number of possible random contacts. We present a simple example, where the group size of deterministic contacts is two, and the graph of random contacts is complete.
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spelling pubmed-99300382023-02-15 A free boundary problem-in time-for the spread of Covid-19 Luckhaus, Stephan Stevens, Angela J Math Biol Article In this paper we deal with two aspects of the Covid epidemic. The first is a phase change during the epidemic. The empirical observation is that once a certain threshold of active infections is reached, the rate of infection is increasing significantly. This threshold depends, among others, also on the season. We model this phenomenon as a jump in the coefficient of the virus exposition, giving the force of infection. In a chemical mass action law this coefficient corresponds to the reaction rate. We get a free boundary problem in time, which exhibits deterministic ‘metastability’. In a population which is in a state of herd immunity, still, if the number of imported infections is large enough, an epidemic wave can start. The second aspect is the two scale nature of the infection network. On one hand side, there is always a finite number of reoccuring–deterministic–contacts, and on the other hand there is a large number of possible random contacts. We present a simple example, where the group size of deterministic contacts is two, and the graph of random contacts is complete. Springer Berlin Heidelberg 2023-02-15 2023 /pmc/articles/PMC9930038/ /pubmed/36790624 http://dx.doi.org/10.1007/s00285-023-01881-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Luckhaus, Stephan
Stevens, Angela
A free boundary problem-in time-for the spread of Covid-19
title A free boundary problem-in time-for the spread of Covid-19
title_full A free boundary problem-in time-for the spread of Covid-19
title_fullStr A free boundary problem-in time-for the spread of Covid-19
title_full_unstemmed A free boundary problem-in time-for the spread of Covid-19
title_short A free boundary problem-in time-for the spread of Covid-19
title_sort free boundary problem-in time-for the spread of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930038/
https://www.ncbi.nlm.nih.gov/pubmed/36790624
http://dx.doi.org/10.1007/s00285-023-01881-0
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