Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected r...

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Detalles Bibliográficos
Autores principales: Erdem, Hakan, Baymakova, Magdalena, Alkan, Sevil, Letaief, Amel, Yahia, Wissal Ben, Dayyab, Farouq, Kolovani, Entela, Grgic, Svjetlana, Cosentino, Federica, Hasanoglu, Imran, Khedr, Reham, Marino, Andrea, Pekok, Abdullah Umut, Eser, Fatma, Arapovic, Jurica, Guner, Hatice Rahmet, Miftode, Ionela-Larisa, Poposki, Kostadin, Sanlidag, Gamze, Tahmaz, Alper, Sipahi, Oguz Resat, Miftode, Egidia Gabriela, Oncu, Serkan, Cagla-Sonmezer, Meliha, Addepalli, Syam Kumar, Darazam, Ilad Alavi, Kumari, Hema Prakash, Koc, Meliha Meriç, Kumar, Meela Ranjith, Sayana, Suresh Babu, Wegdan, Ahmed Ashraf, Amer, Fatma, Ceylan, Mehmet Resat, El-Kholy, Amani, Onder, Taylan, Tehrani, Hamed Azhdari, Hakamifard, Atousa, Kayaaslan, Bircan, Shehata, Ghaydaa, Caskurlu, Hulya, El-Sayed, Nagwa Mostafa, Mortazavi, Seyed Erfan, Pourali, Mohammad, Elbahr, Umran, Kulzhanova, Sholpan, Yetisyigit, Tarkan, Saad, Sahar Ahmed, Cag, Yasemin, Eser-Karlidag, Gulden, Pshenichnaya, Natalia, Belitova, Maya, Akhtar, Nasim, Al-Majid, Fahad, Ayhan, Muge, Khan, Mumtaz Ali, Lanzafame, Massimiliano, Makek, Mateja Jankovic, Nsutebu, Emmanuel, Cascio, Antonio, Dindar-Demiray, Emine Kubra, Evren, Emine Unal, Kalas, Rama, Kalem, Ayşe Kaya, Baljić, Rusmir, Ikram, Aamer, Kaya, Selcuk, Liskova, Anna, Szabo, Balint Gergely, Rahimi, Bilal Ahmad, Mutlu-Yilmaz, Esmeray, Sener, Alper, Rello, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930069/
https://www.ncbi.nlm.nih.gov/pubmed/36790531
http://dx.doi.org/10.1007/s10096-023-04561-5
Descripción
Sumario:Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies). This research included 788 patients. FUO diagnoses were as follows: infections (51.6%; n = 407), neoplasms (11.4%, n = 90), collagen vascular disorders (9.3%, n = 73), undiagnosed (20.1%, n = 158), miscellaneous diseases (7.7%, n = 60). The most common infections were tuberculosis (n = 45, 5.7%), brucellosis (n = 39, 4.9%), rickettsiosis (n = 23, 2.9%), HIV infection (n = 20, 2.5%), and typhoid fever (n = 13, 1.6%). Cardiovascular infections (n = 56, 7.1%) were the most common infectious syndromes. Only collagen vascular disorders were reported significantly more from developed countries (RR = 2.00, 95% CI: 1.19–3.38). FUO had similar characteristics in LI/LMI and UMI/HI countries including the portion of undiagnosed cases (OR, 95% CI; 0.87 (0.65–1.15)), death attributed to FUO (RR = 0.87, 95% CI: 0.65–1.15, p-value = 0.3355), and the mean duration until diagnosis (p = 0.9663). Various aspects of FUO cannot be determined by the economic development solely. Other development indices can be considered in future analyses. Physicians in different countries should be equally prepared for FUO patients.

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