Cargando…

MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition

Pharmacological inhibition of KRAS>RAF>MEK1/2>ERK1/2 signaling has provided no clinical benefit to patients with pancreatic ductal adenocarcinoma (PDAC). Interestingly, combined inhibition of MEK1/2 (with trametinib [T]) plus autophagy (with chloroquine [CQ] or hydroxychloroquine [HCQ]) dem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silvis, Mark R., Silva, Dilru, Rohweder, Riley, Schuman, Sophia, Gudipaty, Swapna, Truong, Amanda, Yap, Jeffrey, Affolter, Kajsa, McMahon, Martin, Kinsey, Conan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930170/ https://www.ncbi.nlm.nih.gov/pubmed/36719686 http://dx.doi.org/10.1084/jem.20221524

Ejemplares similares

Clarifying misbeliefs about hydroxychloroquine (HCQ): developing the HCQ benefits versus harm decision aid (HCQ-SAFE) per low health literacy standards
por: Garg, Shivani, et al.
Publicado: (2023)

Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues
por: Mohanta, Tapan Kumar, et al.
Publicado: (2020)

Quantitative Fundus Autofluorescence in HCQ Retinopathy
por: Greenstein, Vivienne C., et al.
Publicado: (2020)

Pharmacist's perspective on HCQ treatment of COVID‐19
por: Wang, Ya‐Ling, et al.
Publicado: (2020)

Hydroxychloroquine (HCQ): real treatment or false hope?
por: El Bakkouri, Karim
Publicado: (2021)

HCQ induced QT prolongation- Primum non nocere
por: Mahendran, A.J., et al.
Publicado: (2020)

HCQ use not protective against SARS-CoV-2
por: Onuora, Sarah
Publicado: (2020)

Can HCQ Be Considered a “Safe Weapon” for COVID-19 in the Indian Population?
por: Thangaraju, Pugazhenthan, et al.
Publicado: (2020)

Functional interplay between PPM1G and the transcription elongation machinery
por: Gudipaty, Swapna Aravind, et al.
Publicado: (2016)

Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
por: Masson, Jean-Daniel, et al.
Publicado: (2020)

HCQ prophylaxis in COVID-19 did not show any QTc prolongation in Healthcare workers
por: Jha, Sujeet, et al.
Publicado: (2021)

Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis
por: Gao, Mingjun, et al.
Publicado: (2021)

The efficacy and safety of hydroxychloroquine (HCQ) in treatment of COVID19 –a systematic review and meta-analysis
por: Choudhuri, Anirban Hom, et al.
Publicado: (2021)

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy
por: Krueger, Janna, et al.
Publicado: (2021)

Scaling the immune incline in PDAC
por: Rojas, Luis A., et al.
Publicado: (2021)

Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC)
por: Wijnen, Rosa, et al.
Publicado: (2021)

Control of Expression of Key Cell Cycle Enzymes Drives Cell Line-Specific Functions of CDK7 in Human PDAC Cells
por: Kolloch, Lina, et al.
Publicado: (2022)

Analogue discovery of safer alternatives to HCQ and CQ drugs for SAR-CoV-2 by computational design
por: Sinha, Meetali, et al.
Publicado: (2021)

The ‘myth of Hydroxychloroquine (HCQ) as post-exposure prophylaxis (PEP) for the prevention of COVID-19’ is far from reality
por: Dhibar, Deba Prasad, et al.
Publicado: (2023)

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
por: Zeng, Mei, et al.
Publicado: (2018)

Transverse Space Charge Effect During Bunch Compression in PDAC1 and PDAC2 Compressor Ring
por: Franchetti, Giuliano
Publicado: (2000)

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
por: Brown, Matthew, et al.
Publicado: (2020)

Effect of quantitative real-time RT-PCR reaction sensitivity in determining the efficacy of HCQ prophylaxis for COVID-19
por: Gouda, Divakara, et al.
Publicado: (2020)

Autophagy is required for PDAC glutamine metabolism
por: Seo, Ju-Won, et al.
Publicado: (2016)

SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells
por: Li, Siqin, et al.
Publicado: (2016)

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
por: Kinsey, Conan G., et al.
Publicado: (2019)

A Study on Hydroxychloroquine (HCQ) as prophylaxis among Health care worker (HCW) for SARS -Co V-2 infection
por: Ghosh, Anindya, et al.
Publicado: (2021)

Overexpression of Mesothelin in Pancreatic Ductal Adenocarcinoma (PDAC)
por: Le, Kai, et al.
Publicado: (2020)

The Microbiome in PDAC—Vantage Point for Future Therapies?
por: Pfisterer, Nina, et al.
Publicado: (2022)

Cdk2: a key regulator of the senescence control function of Myc
por: Hydbring, Per, et al.
Publicado: (2010)

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
por: Bolin, Sara, et al.
Publicado: (2018)

MEDB-80. CDK8 promotes stemness of MYC-driven medulloblastoma
por: Wang, Dong, et al.
Publicado: (2022)

Ocular toxicity due to Trametinib and Dabrafenib
por: Sarny, Stephanie, et al.
Publicado: (2017)

A real-world analysis of trametinib in combination with hydroxychloroquine or CDK4/6 inhibitor as third- or later-line therapy in metastatic pancreatic adenocarcinoma
por: Tang, Hui, et al.
Publicado: (2023)

Zinc augments the antiviral potential of HCQ/CQ and ivermectin to reduce the risks of more serious outcomes from COVID-19 infection
por: Boretti, Alberto
Publicado: (2022)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
por: Kang, Jian, et al.
Publicado: (2014)

LGG-27. TARGETED THERAPY FOR PEDIATRIC LOW-GRADE GLIOMAS AND PLEXIFORM NEUROFIBROMAS WITH TRAMETINIB
por: Nguyen, Tiffany, et al.
Publicado: (2020)

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3
por: Yin, Qiuyuan, et al.
Publicado: (2020)

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
por: Huang, Chun-Hao, et al.
Publicado: (2014)

MYC Modulation around the CDK2/p27/SKP2 Axis
por: Hydbring, Per, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_2359bbnho7us2f6kk6rphe69p7