Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity

BACKGROUND: Galectin-3 (Gal-3), the only chimeric β-galactosides-binding lectin, consists of Gal-3N (N-terminal regulatory peptide) and Gal-3C (C-terminal carbohydrate-recognition domain). Interestingly, Gal-3C could specifically inhibit endogenous full-length Gal-3 to exhibit anti-tumor activity. H...

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Detalles Bibliográficos
Autores principales: Gao, Xiaoge, Jiang, Pin, Wei, Xiaohuan, Zhang, Wei, Zheng, Jiwei, Sun, Shishuo, Yao, Hong, Liu, Xiangye, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930235/
https://www.ncbi.nlm.nih.gov/pubmed/36793021
http://dx.doi.org/10.1186/s12885-023-10608-9

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