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Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link
The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system. Several studies have...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930263/ https://www.ncbi.nlm.nih.gov/pubmed/36788562 http://dx.doi.org/10.1186/s40885-022-00229-y |
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author | Awasthi, Richa Manger, Priyanka Thapa Khare, Rajesh Kumar |
author_facet | Awasthi, Richa Manger, Priyanka Thapa Khare, Rajesh Kumar |
author_sort | Awasthi, Richa |
collection | PubMed |
description | The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system. Several studies have reported mixed results with respect to relationship of VDR gene and hypertension. Observational evidence supports the concept that vitamin D plays a role in the pathogenesis of cardiovascular disease and arterial hypertension which is further supported by meta-analysis and case control studies reporting how VDR polymorphism leads to the onset and development of hypertension. In this review, we summarize the existing literature on the link between VDR and hypertension, including mechanistic studies, observational data, and clinical trials showing relationship of vitamin D level and hypertension with a focus on recent findings related to genetic studies that showed the relationship of VDR gene polymorphism with vitamin D level in hypertensive and normotensive groups. As a result, determining the association of VDR polymorphisms with essential hypertension is expected to aid in the risk assessment for the condition. |
format | Online Article Text |
id | pubmed-9930263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99302632023-02-16 Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link Awasthi, Richa Manger, Priyanka Thapa Khare, Rajesh Kumar Clin Hypertens Review The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system. Several studies have reported mixed results with respect to relationship of VDR gene and hypertension. Observational evidence supports the concept that vitamin D plays a role in the pathogenesis of cardiovascular disease and arterial hypertension which is further supported by meta-analysis and case control studies reporting how VDR polymorphism leads to the onset and development of hypertension. In this review, we summarize the existing literature on the link between VDR and hypertension, including mechanistic studies, observational data, and clinical trials showing relationship of vitamin D level and hypertension with a focus on recent findings related to genetic studies that showed the relationship of VDR gene polymorphism with vitamin D level in hypertensive and normotensive groups. As a result, determining the association of VDR polymorphisms with essential hypertension is expected to aid in the risk assessment for the condition. BioMed Central 2023-02-15 /pmc/articles/PMC9930263/ /pubmed/36788562 http://dx.doi.org/10.1186/s40885-022-00229-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Awasthi, Richa Manger, Priyanka Thapa Khare, Rajesh Kumar Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title | Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title_full | Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title_fullStr | Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title_full_unstemmed | Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title_short | Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link |
title_sort | fok i and bsm i gene polymorphism of vitamin d receptor and essential hypertension: a mechanistic link |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930263/ https://www.ncbi.nlm.nih.gov/pubmed/36788562 http://dx.doi.org/10.1186/s40885-022-00229-y |
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