Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors

BACKGROUND: Spiroindolone and pyrazoleamide antimalarial compounds target Plasmodium falciparum P-type ATPase (PfATP4) and induce disruption of intracellular Na(+) homeostasis. Recently, a PfATP4 mutation was discovered that confers resistance to a pyrazoleamide while increasing sensitivity to a spi...

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Detalles Bibliográficos
Autores principales: Tewari, Shivendra G., Elahi, Rubayet, Kwan, Bobby, Rajaram, Krithika, Bhatnagar, Suyash, Reifman, Jaques, Prigge, Sean T., Vaidya, Akhil B., Wallqvist, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930341/
https://www.ncbi.nlm.nih.gov/pubmed/36788578
http://dx.doi.org/10.1186/s12936-023-04481-x

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