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Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India
PURPOSE OF THE STUDY: Renal mass lesions in majority of the cases are due to malignant etiology and about one-third of them are reported with metastatic lesions at the time of presentation. Thus proper investigational workup is needed for staging and thereby treatment planning. The current fluorine1...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930448/ https://www.ncbi.nlm.nih.gov/pubmed/36817204 http://dx.doi.org/10.4103/ijnm.ijnm_41_22 |
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author | Sri Charan, Kommu Bikshapathy Kalawat, Tekchand Priya, Rallapeta Ramya Nallabothula, Anil Kumar Manthri, Ranadheer Gupta Reddy, Singareddy Chandrateja Narendra, Hulikal Rukmangadha, Nandyala Kale, Pavan Kumar G Ajit, Nimmagadda |
author_facet | Sri Charan, Kommu Bikshapathy Kalawat, Tekchand Priya, Rallapeta Ramya Nallabothula, Anil Kumar Manthri, Ranadheer Gupta Reddy, Singareddy Chandrateja Narendra, Hulikal Rukmangadha, Nandyala Kale, Pavan Kumar G Ajit, Nimmagadda |
author_sort | Sri Charan, Kommu Bikshapathy |
collection | PubMed |
description | PURPOSE OF THE STUDY: Renal mass lesions in majority of the cases are due to malignant etiology and about one-third of them are reported with metastatic lesions at the time of presentation. Thus proper investigational workup is needed for staging and thereby treatment planning. The current fluorine18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F18-FDG PET/CT) study was designed to characterize renal mass lesions metabolically and identifying other metabolically active lesions in the body suggesting metastatic disease. MATERIALS AND METHODS: A total of 24 patients (males – 18 and females – 6) with a mean age of 53.8 ± 12.3 years were recruited in this study for dual time-point PET/CT scan. All patients with renal mass lesions underwent contrast-enhanced CT prior to PET/CT. Metabolic parameters such as maximum standardized uptake value (max.SUV) with a cut off ≥2.5 and retention index (RI) of ≥10% were used to label the lesion as malignant and remaining less than cutoff as benign. The final diagnosis of lesion on imaging was confirmed with a histopathological examination (HPE). RESULTS: Using max.SUV cut off value, 17/24 renal mass lesions were characterized as malignant and remaining 7/24 renal lesions of benign etiology. PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80%, 75%, 94.1%, 42.8%, and 79.1%, respectively, by considering HPE as a gold standard. Nine patients were diagnosed with distant site involvement suggestive of metastases. CONCLUSION: F18-FDG PET/CT can efficiently characterize solid renal mass lesion as benign and malignant using metabolic parameters such as max.SUV and RI. In addition, whole-body survey identified distant site involvement in 25% of the patients, thus contributing change in management. |
format | Online Article Text |
id | pubmed-9930448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-99304482023-02-16 Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India Sri Charan, Kommu Bikshapathy Kalawat, Tekchand Priya, Rallapeta Ramya Nallabothula, Anil Kumar Manthri, Ranadheer Gupta Reddy, Singareddy Chandrateja Narendra, Hulikal Rukmangadha, Nandyala Kale, Pavan Kumar G Ajit, Nimmagadda Indian J Nucl Med Original Article PURPOSE OF THE STUDY: Renal mass lesions in majority of the cases are due to malignant etiology and about one-third of them are reported with metastatic lesions at the time of presentation. Thus proper investigational workup is needed for staging and thereby treatment planning. The current fluorine18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F18-FDG PET/CT) study was designed to characterize renal mass lesions metabolically and identifying other metabolically active lesions in the body suggesting metastatic disease. MATERIALS AND METHODS: A total of 24 patients (males – 18 and females – 6) with a mean age of 53.8 ± 12.3 years were recruited in this study for dual time-point PET/CT scan. All patients with renal mass lesions underwent contrast-enhanced CT prior to PET/CT. Metabolic parameters such as maximum standardized uptake value (max.SUV) with a cut off ≥2.5 and retention index (RI) of ≥10% were used to label the lesion as malignant and remaining less than cutoff as benign. The final diagnosis of lesion on imaging was confirmed with a histopathological examination (HPE). RESULTS: Using max.SUV cut off value, 17/24 renal mass lesions were characterized as malignant and remaining 7/24 renal lesions of benign etiology. PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80%, 75%, 94.1%, 42.8%, and 79.1%, respectively, by considering HPE as a gold standard. Nine patients were diagnosed with distant site involvement suggestive of metastases. CONCLUSION: F18-FDG PET/CT can efficiently characterize solid renal mass lesion as benign and malignant using metabolic parameters such as max.SUV and RI. In addition, whole-body survey identified distant site involvement in 25% of the patients, thus contributing change in management. Wolters Kluwer - Medknow 2022 2022-12-02 /pmc/articles/PMC9930448/ /pubmed/36817204 http://dx.doi.org/10.4103/ijnm.ijnm_41_22 Text en Copyright: © 2022 Indian Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sri Charan, Kommu Bikshapathy Kalawat, Tekchand Priya, Rallapeta Ramya Nallabothula, Anil Kumar Manthri, Ranadheer Gupta Reddy, Singareddy Chandrateja Narendra, Hulikal Rukmangadha, Nandyala Kale, Pavan Kumar G Ajit, Nimmagadda Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title | Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title_full | Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title_fullStr | Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title_full_unstemmed | Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title_short | Utility of Fluorine18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Metabolic Characterization of Solid Renal Mass Lesion and Localization of Extra Renal Lesions in the Body – A Prospective Study from the Tertiary Care Center in South India |
title_sort | utility of fluorine18 fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in metabolic characterization of solid renal mass lesion and localization of extra renal lesions in the body – a prospective study from the tertiary care center in south india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930448/ https://www.ncbi.nlm.nih.gov/pubmed/36817204 http://dx.doi.org/10.4103/ijnm.ijnm_41_22 |
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