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Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and 7b exhibited potent to strong anticancer activity that was nearly comparable...

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Detalles Bibliográficos
Autores principales:	El-Zoghbi, Mona S., El-Sebaey, Samiha A., AL-Ghulikah, Hanan A., Sobh, Eman A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930781/ https://www.ncbi.nlm.nih.gov/pubmed/36776024 http://dx.doi.org/10.1080/14756366.2023.2175209

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