Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp

Four dimeric diketopiperazine stereoisomers (1–4) including two new ones (1–2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compound...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xinyang, Xu, Jinzhong, Wang, Pinmei, Ding, Wanjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/
https://www.ncbi.nlm.nih.gov/pubmed/36816774
http://dx.doi.org/10.1080/21501203.2022.2069173
_version_ 1784889114457276416
author Li, Xinyang
Xu, Jinzhong
Wang, Pinmei
Ding, Wanjing
author_facet Li, Xinyang
Xu, Jinzhong
Wang, Pinmei
Ding, Wanjing
author_sort Li, Xinyang
collection PubMed
description Four dimeric diketopiperazine stereoisomers (1–4) including two new ones (1–2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey’s method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.
format Online
Article
Text
id pubmed-9930829
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-99308292023-02-16 Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp Li, Xinyang Xu, Jinzhong Wang, Pinmei Ding, Wanjing Mycology Research Article Four dimeric diketopiperazine stereoisomers (1–4) including two new ones (1–2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey’s method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method. Taylor & Francis 2022-04-29 /pmc/articles/PMC9930829/ /pubmed/36816774 http://dx.doi.org/10.1080/21501203.2022.2069173 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Xinyang
Xu, Jinzhong
Wang, Pinmei
Ding, Wanjing
Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title_full Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title_fullStr Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title_full_unstemmed Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title_short Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp
title_sort novel indole diketopiperazine stereoisomers from a marine-derived fungus aspergillus sp
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/
https://www.ncbi.nlm.nih.gov/pubmed/36816774
http://dx.doi.org/10.1080/21501203.2022.2069173
work_keys_str_mv AT lixinyang novelindolediketopiperazinestereoisomersfromamarinederivedfungusaspergillussp
AT xujinzhong novelindolediketopiperazinestereoisomersfromamarinederivedfungusaspergillussp
AT wangpinmei novelindolediketopiperazinestereoisomersfromamarinederivedfungusaspergillussp
AT dingwanjing novelindolediketopiperazinestereoisomersfromamarinederivedfungusaspergillussp

Ejemplares similares