Clinical Significance of Somatic Mutations in RAS/RAF/MAPK Signaling Pathway in Moroccan and North African Colorectal Cancer Patients

BACKGROUND: Mutations in RAS (KRAS, NRAS) and BRAF genes are the main biomarker predicting response to anti-EGFR monoclonal antibodies in targeted therapy in colorectal cancer (CRC). OBJECTIVE: Our study aims to evaluate the frequencies of KRAS, NRAS and BRAF mutations and their possible association...

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Detalles Bibliográficos
Autores principales: Benmokhtar, Soukaina, Laraqui, Abdelilah, El Boukhrissi, Fatima, Hilali, Farida, Bajjou, Tahar, Jafari, Meryem, Elzaitouni, Sara, Baba, Walid, El Mchichi, Bouchra, Elannaz, Hicham, Lahlou, Idriss Amine, Chahdi, Hafsa, Oukabli, Mohamed, Mahfoud, Tarik, Tanz, Rachid, Ichou, Mohamed, Ennibi, Khaled, Dakka, Nadia, Sekhsokh, Yassine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930961/
https://www.ncbi.nlm.nih.gov/pubmed/36444585
http://dx.doi.org/10.31557/APJCP.2022.23.11.3725

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