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Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial

Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to...

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Autores principales: Lago, Jamile, Fraga, Deborah, Guimarães, Luiz Henrique, Lago, Tainã, Santos, Yuri, Lago, Ednaldo, Werneck, Guilherme L., Bacellar, Olívia, Carvalho, Edgar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931096/
https://www.ncbi.nlm.nih.gov/pubmed/36791065
http://dx.doi.org/10.1371/journal.pntd.0011064
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author Lago, Jamile
Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
author_facet Lago, Jamile
Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
author_sort Lago, Jamile
collection PubMed
description Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to humans. However, dogs may remain with chronic ulcers for a long time, and as there are no public policies about CTL, these animals die or are sacrificed. Here we compare the efficacy of intralesional meglumine antimoniate with intralesional 0.9% NaCl solution in CTL treatment. This randomized control study included 32 dogs with cutaneous or muzzle lesions who had L. braziliensis DNA detected by PCR in tissue biopsied. Group one received 5ml of intralesional Glucantime, and group two received 5ml 0.9% NaCl solution, both applied in the four cardinal points on days 0, 15, and 30. Cure was defined as complete healing of the ulcers in the absence of raised borders on day 90. There was no difference in animals’ demographic and clinical features in the two groups (p >.05). While at the endpoint, the cure rate was 87.5% in the group test, and in those who received 0.9 NaCl the cure rate was only 12.5%. As important as the high cure rate, the healing time was faster in dogs treated with antimony than in those treated with saline (p < .001). Intralesional meglumine antimoniate is effective in the treatment of dogs with L. braziliensis infection and accelerates the healing time of CTL.
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spelling pubmed-99310962023-02-16 Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial Lago, Jamile Fraga, Deborah Guimarães, Luiz Henrique Lago, Tainã Santos, Yuri Lago, Ednaldo Werneck, Guilherme L. Bacellar, Olívia Carvalho, Edgar M. PLoS Negl Trop Dis Research Article Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to humans. However, dogs may remain with chronic ulcers for a long time, and as there are no public policies about CTL, these animals die or are sacrificed. Here we compare the efficacy of intralesional meglumine antimoniate with intralesional 0.9% NaCl solution in CTL treatment. This randomized control study included 32 dogs with cutaneous or muzzle lesions who had L. braziliensis DNA detected by PCR in tissue biopsied. Group one received 5ml of intralesional Glucantime, and group two received 5ml 0.9% NaCl solution, both applied in the four cardinal points on days 0, 15, and 30. Cure was defined as complete healing of the ulcers in the absence of raised borders on day 90. There was no difference in animals’ demographic and clinical features in the two groups (p >.05). While at the endpoint, the cure rate was 87.5% in the group test, and in those who received 0.9 NaCl the cure rate was only 12.5%. As important as the high cure rate, the healing time was faster in dogs treated with antimony than in those treated with saline (p < .001). Intralesional meglumine antimoniate is effective in the treatment of dogs with L. braziliensis infection and accelerates the healing time of CTL. Public Library of Science 2023-02-15 /pmc/articles/PMC9931096/ /pubmed/36791065 http://dx.doi.org/10.1371/journal.pntd.0011064 Text en © 2023 Lago et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lago, Jamile
Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title_full Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title_fullStr Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title_full_unstemmed Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title_short Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial
title_sort efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931096/
https://www.ncbi.nlm.nih.gov/pubmed/36791065
http://dx.doi.org/10.1371/journal.pntd.0011064
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