Cargando…

Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis

BACKGROUND: The UNC13A gene is an established susceptibility locus for amyotrophic lateral sclerosis (ALS) and a determinant of shorter survival after disease onset, with up to 33.0 months difference in life expectancy for carriers of the rs12608932 risk genotype. However, its overall effect on othe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manini, Arianna, Casiraghi, Valeria, Brusati, Alberto, Maranzano, Alessio, Gentile, Francesco, Colombo, Eleonora, Bonetti, Ruggero, Peverelli, Silvia, Invernizzi, Sabrina, Gentilini, Davide, Messina, Stefano, Verde, Federico, Poletti, Barbara, Fogh, Isabella, Morelli, Claudia, Silani, Vincenzo, Ratti, Antonia, Ticozzi, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931189/ https://www.ncbi.nlm.nih.gov/pubmed/36819716 http://dx.doi.org/10.3389/fnagi.2023.1067954

Ejemplares similares

TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis
por: Manini, Arianna, et al.
Publicado: (2022)

Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis
por: Verde, Federico, et al.
Publicado: (2023)

Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis
por: Verde, Federico, et al.
Publicado: (2022)

Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study
por: Pasquini, Jacopo, et al.
Publicado: (2022)

Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2022)

Correction to: Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis
por: Maranzano, Alessio, et al.
Publicado: (2023)

Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects
por: Brusati, Alberto, et al.
Publicado: (2022)

The impact of upper motor neuron involvement on clinical features, disease progression and prognosis in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2022)

Correction to: Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2023)

Epileptic Capgras-Like Delusions in a Patient with Right Frontal Meningioma: Case Report
por: Colombo, Eleonora, et al.
Publicado: (2021)

Serum neurofilament light chain levels in Covid-19 patients without major neurological manifestations
por: Verde, Federico, et al.
Publicado: (2022)

Feasibility and diagnostics of the Frontal Assessment Battery (FAB) in amyotrophic lateral sclerosis
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Prevalence and determinants of language impairment in non‐demented amyotrophic lateral sclerosis patients
por: Solca, Federica, et al.
Publicado: (2022)

Diagnostics and clinical usability of the Montreal Cognitive Assessment (MoCA) in amyotrophic lateral sclerosis
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Emotional Processing and Experience in Amyotrophic Lateral Sclerosis: A Systematic and Critical Review
por: Carelli, Laura, et al.
Publicado: (2021)

Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders
por: Poletti, Barbara, et al.
Publicado: (2021)

Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis
por: Carlomagno, C., et al.
Publicado: (2020)

TARDBP mutations in a cohort of Italian patients with Parkinson’s disease and atypical parkinsonisms
por: Tiloca, Cinzia, et al.
Publicado: (2022)

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis
por: Gaastra, Benjamin, et al.
Publicado: (2016)

Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Verde, Federico, et al.
Publicado: (2021)

Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease
por: Poletti, Barbara, et al.
Publicado: (2022)

MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis
por: Ye, Shan, et al.
Publicado: (2022)

Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis
por: Chen, Qiao Yi, et al.
Publicado: (2022)

Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis
por: Jeon, Yu-Mi, et al.
Publicado: (2023)

Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis
por: Manera, Umberto, et al.
Publicado: (2023)

The Distinct Traits of the UNC13A Polymorphism in Amyotrophic Lateral Sclerosis
por: Tan, Harold H. G., et al.
Publicado: (2020)

Diagnostic properties of the Italian ECAS Carer Interview (ECAS-CI)
por: Poletti, Barbara, et al.
Publicado: (2022)

Towards Understanding the Relationship Between ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis
por: Zhao, Chenxuan, et al.
Publicado: (2022)

Clinical and molecular features of patients with amyotrophic lateral sclerosis and SOD1 mutations: a monocentric study
por: Gagliardi, Delia, et al.
Publicado: (2023)

Genetic and clinical analysis of TP73 gene in amyotrophic lateral sclerosis patients from Chinese mainland
por: Tang, Xuxiong, et al.
Publicado: (2023)

The Frontal Assessment Battery (FAB) effectively discriminates between MCI and dementia within the clinical spectrum of neurochemically confirmed Alzheimer’s disease
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis in seven provinces of Chinese mainland: A cross-sectional survey from 2015 to 2016
por: Zhang, Jie, et al.
Publicado: (2022)

Selective and Inverse U-Shaped Curve Alteration of the Retinal Nerve in Amyotrophic Lateral Sclerosis: A Potential Mirror of the Disease
por: Zhang, Yixuan, et al.
Publicado: (2022)

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform
por: Pun, Frank W., et al.
Publicado: (2022)

UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target
por: Willemse, Sean W, et al.
Publicado: (2023)

Staphylococcus aureus phagocytosis is affected by senescence
por: Robledo, Esteban, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eqfafnt0ce10r7pddms5ltr3dp