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Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli

The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translationa...

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Autores principales: Chao, Tzu-Hao Harry, Lee, Byeongwook, Hsu, Li-Ming, Cerri, Domenic Hayden, Zhang, Wei-Ting, Wang, Tzu-Wen Winnie, Ryali, Srikanth, Menon, Vinod, Shih, Yen-Yu Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931216/
https://www.ncbi.nlm.nih.gov/pubmed/36791185
http://dx.doi.org/10.1126/sciadv.ade5732
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author Chao, Tzu-Hao Harry
Lee, Byeongwook
Hsu, Li-Ming
Cerri, Domenic Hayden
Zhang, Wei-Ting
Wang, Tzu-Wen Winnie
Ryali, Srikanth
Menon, Vinod
Shih, Yen-Yu Ian
author_facet Chao, Tzu-Hao Harry
Lee, Byeongwook
Hsu, Li-Ming
Cerri, Domenic Hayden
Zhang, Wei-Ting
Wang, Tzu-Wen Winnie
Ryali, Srikanth
Menon, Vinod
Shih, Yen-Yu Ian
author_sort Chao, Tzu-Hao Harry
collection PubMed
description The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translational utility. Here, we combine fiber photometry with functional magnetic resonance imaging (fMRI) and computational modeling to characterize dynamics of putative rat DMN nodes and their interactions with the anterior insular cortex (AI) of the salience network. Our analysis revealed neuronal activity changes in AI and DMN nodes preceding fMRI-derived DMN activations and cyclical transitions between brain network states. Furthermore, we demonstrate that salient oddball stimuli suppress the DMN and enhance AI neuronal activity and that the AI causally inhibits the retrosplenial cortex, a prominent DMN node. These findings elucidate the neurophysiological foundations of the rodent DMN, its spatiotemporal dynamical properties, and modulation by salient stimuli, paving the way for future translational studies.
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spelling pubmed-99312162023-02-16 Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli Chao, Tzu-Hao Harry Lee, Byeongwook Hsu, Li-Ming Cerri, Domenic Hayden Zhang, Wei-Ting Wang, Tzu-Wen Winnie Ryali, Srikanth Menon, Vinod Shih, Yen-Yu Ian Sci Adv Neuroscience The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translational utility. Here, we combine fiber photometry with functional magnetic resonance imaging (fMRI) and computational modeling to characterize dynamics of putative rat DMN nodes and their interactions with the anterior insular cortex (AI) of the salience network. Our analysis revealed neuronal activity changes in AI and DMN nodes preceding fMRI-derived DMN activations and cyclical transitions between brain network states. Furthermore, we demonstrate that salient oddball stimuli suppress the DMN and enhance AI neuronal activity and that the AI causally inhibits the retrosplenial cortex, a prominent DMN node. These findings elucidate the neurophysiological foundations of the rodent DMN, its spatiotemporal dynamical properties, and modulation by salient stimuli, paving the way for future translational studies. American Association for the Advancement of Science 2023-02-15 /pmc/articles/PMC9931216/ /pubmed/36791185 http://dx.doi.org/10.1126/sciadv.ade5732 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroscience
Chao, Tzu-Hao Harry
Lee, Byeongwook
Hsu, Li-Ming
Cerri, Domenic Hayden
Zhang, Wei-Ting
Wang, Tzu-Wen Winnie
Ryali, Srikanth
Menon, Vinod
Shih, Yen-Yu Ian
Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title_full Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title_fullStr Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title_full_unstemmed Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title_short Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
title_sort neuronal dynamics of the default mode network and anterior insular cortex: intrinsic properties and modulation by salient stimuli
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931216/
https://www.ncbi.nlm.nih.gov/pubmed/36791185
http://dx.doi.org/10.1126/sciadv.ade5732
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