Cargando…
Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translationa...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931216/ https://www.ncbi.nlm.nih.gov/pubmed/36791185 http://dx.doi.org/10.1126/sciadv.ade5732 |
_version_ | 1784889199205285888 |
---|---|
author | Chao, Tzu-Hao Harry Lee, Byeongwook Hsu, Li-Ming Cerri, Domenic Hayden Zhang, Wei-Ting Wang, Tzu-Wen Winnie Ryali, Srikanth Menon, Vinod Shih, Yen-Yu Ian |
author_facet | Chao, Tzu-Hao Harry Lee, Byeongwook Hsu, Li-Ming Cerri, Domenic Hayden Zhang, Wei-Ting Wang, Tzu-Wen Winnie Ryali, Srikanth Menon, Vinod Shih, Yen-Yu Ian |
author_sort | Chao, Tzu-Hao Harry |
collection | PubMed |
description | The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translational utility. Here, we combine fiber photometry with functional magnetic resonance imaging (fMRI) and computational modeling to characterize dynamics of putative rat DMN nodes and their interactions with the anterior insular cortex (AI) of the salience network. Our analysis revealed neuronal activity changes in AI and DMN nodes preceding fMRI-derived DMN activations and cyclical transitions between brain network states. Furthermore, we demonstrate that salient oddball stimuli suppress the DMN and enhance AI neuronal activity and that the AI causally inhibits the retrosplenial cortex, a prominent DMN node. These findings elucidate the neurophysiological foundations of the rodent DMN, its spatiotemporal dynamical properties, and modulation by salient stimuli, paving the way for future translational studies. |
format | Online Article Text |
id | pubmed-9931216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99312162023-02-16 Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli Chao, Tzu-Hao Harry Lee, Byeongwook Hsu, Li-Ming Cerri, Domenic Hayden Zhang, Wei-Ting Wang, Tzu-Wen Winnie Ryali, Srikanth Menon, Vinod Shih, Yen-Yu Ian Sci Adv Neuroscience The default mode network (DMN) is critical for self-referential mental processes, and its dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological properties and task-based functional organization of the rodent DMN are poorly understood, limiting its translational utility. Here, we combine fiber photometry with functional magnetic resonance imaging (fMRI) and computational modeling to characterize dynamics of putative rat DMN nodes and their interactions with the anterior insular cortex (AI) of the salience network. Our analysis revealed neuronal activity changes in AI and DMN nodes preceding fMRI-derived DMN activations and cyclical transitions between brain network states. Furthermore, we demonstrate that salient oddball stimuli suppress the DMN and enhance AI neuronal activity and that the AI causally inhibits the retrosplenial cortex, a prominent DMN node. These findings elucidate the neurophysiological foundations of the rodent DMN, its spatiotemporal dynamical properties, and modulation by salient stimuli, paving the way for future translational studies. American Association for the Advancement of Science 2023-02-15 /pmc/articles/PMC9931216/ /pubmed/36791185 http://dx.doi.org/10.1126/sciadv.ade5732 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroscience Chao, Tzu-Hao Harry Lee, Byeongwook Hsu, Li-Ming Cerri, Domenic Hayden Zhang, Wei-Ting Wang, Tzu-Wen Winnie Ryali, Srikanth Menon, Vinod Shih, Yen-Yu Ian Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title | Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title_full | Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title_fullStr | Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title_full_unstemmed | Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title_short | Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli |
title_sort | neuronal dynamics of the default mode network and anterior insular cortex: intrinsic properties and modulation by salient stimuli |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931216/ https://www.ncbi.nlm.nih.gov/pubmed/36791185 http://dx.doi.org/10.1126/sciadv.ade5732 |
work_keys_str_mv | AT chaotzuhaoharry neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT leebyeongwook neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT hsuliming neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT cerridomenichayden neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT zhangweiting neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT wangtzuwenwinnie neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT ryalisrikanth neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT menonvinod neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli AT shihyenyuian neuronaldynamicsofthedefaultmodenetworkandanteriorinsularcortexintrinsicpropertiesandmodulationbysalientstimuli |