Impaired iron recycling from erythrocytes is an early hallmark of aging

Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by splenic red pulp macrophages (RPMs) via erythrophagocytosis. Given that RPMs...

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Detalles Bibliográficos
Autores principales: Slusarczyk, Patryk, Mandal, Pratik Kumar, Zurawska, Gabriela, Niklewicz, Marta, Chouhan, Komal, Mahadeva, Raghunandan, Jończy, Aneta, Macias, Matylda, Szybinska, Aleksandra, Cybulska-Lubak, Magdalena, Krawczyk, Olga, Herman, Sylwia, Mikula, Michal, Serwa, Remigiusz, Lenartowicz, Małgorzata, Pokrzywa, Wojciech, Mleczko-Sanecka, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931393/
https://www.ncbi.nlm.nih.gov/pubmed/36719185
http://dx.doi.org/10.7554/eLife.79196

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