Soluble Epoxide Hydrolase Inhibitor TPPU Alleviates Nab-Paclitaxel-Induced Peripheral Neuropathic Pain via Suppressing NF-κB Signalling in the Spinal Cord of a Rat

OBJECTIVE: Paclitaxel-induced peripheral neuropathy (PIPN) is a debilitating and difficult-to-treat side effect of paclitaxel. Soluble epoxide hydrolase (sEH) can rapidly metabolize the endogenous anti-inflammatory mediators' epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids. Th...

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Detalles Bibliográficos
Autores principales: Wei, Xing, Jia, Lijun, Zhou, Yaqing, Li, Weimiao, Shan, Changyou, Zhang, Shuqun, Zhao, Yonglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931472/
https://www.ncbi.nlm.nih.gov/pubmed/36819745
http://dx.doi.org/10.1155/2023/9058774

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