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Mutational fitness landscape of human influenza H3N2 neuraminidase

Influenza neuraminidase (NA) has received increasing attention as an effective vaccine target. However, its mutational tolerance is not well characterized. Here, the fitness effects of >6,000 mutations in human H3N2 NA are probed using deep mutational scanning. Our result shows that while its ant...

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Detalles Bibliográficos
Autores principales:	Lei, Ruipeng, Garcia, Andrea Hernandez, Tan, Timothy J.C., Teo, Qi Wen, Wang, Yiquan, Zhang, Xiwen, Luo, Shitong, Nair, Satish K., Peng, Jian, Wu, Nicholas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931530/ https://www.ncbi.nlm.nih.gov/pubmed/36640354 http://dx.doi.org/10.1016/j.celrep.2022.111951

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