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Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Intramembrane proteases play a pivotal role in biology and medicine, but how these proteases decode cleavability of a substrate transmembrane (TM) domain remains unclear. Here, we study the role of conformational flexibility of a TM domain, as determined by deuterium/hydrogen exchange, on substrate...

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Detalles Bibliográficos
Autores principales:	Werner, Nadine T., Högel, Philipp, Güner, Gökhan, Stelzer, Walter, Wozny, Manfred, Aßfalg, Marlene, Lichtenthaler, Stefan F., Steiner, Harald, Langosch, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931712/ https://www.ncbi.nlm.nih.gov/pubmed/36792683 http://dx.doi.org/10.1038/s42003-023-04470-5

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