Cargando…

Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue

Cancer-related fatigue (CRF) is a frequent long-term symptom in non-metastasized breast cancer patients (BC). This 4-year follow-up intended to compare the long-term effects of a 10-week multimodal therapy (MT: sleep education, psychoeducation, eurythmy- and painting therapy) and combination therapy...

Descripción completa

Detalles Bibliográficos
Autores principales: Kröz, M., Quittel, F., Reif, M., Zerm, R., Pranga, D., Bartsch, C., Brinkhaus, B., Büssing, A., Gutenbrunner, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931714/
https://www.ncbi.nlm.nih.gov/pubmed/36792620
http://dx.doi.org/10.1038/s41598-022-25322-y
_version_ 1784889292328271872
author Kröz, M.
Quittel, F.
Reif, M.
Zerm, R.
Pranga, D.
Bartsch, C.
Brinkhaus, B.
Büssing, A.
Gutenbrunner, C.
author_facet Kröz, M.
Quittel, F.
Reif, M.
Zerm, R.
Pranga, D.
Bartsch, C.
Brinkhaus, B.
Büssing, A.
Gutenbrunner, C.
author_sort Kröz, M.
collection PubMed
description Cancer-related fatigue (CRF) is a frequent long-term symptom in non-metastasized breast cancer patients (BC). This 4-year follow-up intended to compare the long-term effects of a 10-week multimodal therapy (MT: sleep education, psychoeducation, eurythmy- and painting therapy) and combination therapy [CT: MT plus aerobic training (AT)] to AT-control. BC-patients were randomized or allocated by preference to three arms in a comprehensive cohort study. Primary outcome was a composite score including Pittsburgh Sleep Quality Index (PSQI) and Cancer Fatigue Scale (CFS-D), captured at baseline, after 10 weeks of intervention (T1), 6 months later (T2), and after 4 years (T3). We exploratively tested for superiority of MT and CT versus AT after 4 years (T3) based on the statistical model of the main analysis. Of 126 (65 randomized) BC-patients included, 105 started treatments and 79 were re-assessed for long-term effects (T3). MT and CT were superior over AT after 4 years regarding PSQI/CFS-D and PSQI sum-score, respectively (all p < 0.05), but not for CFS-D. The multimodal and combination treatment for breast cancer patients with CRF indicates sustainable long-term superiority over aerobic training for the outcomes sleep quality and combined sleep quality/fatigue. A confirmative randomized controlled trial is warranted.
format Online
Article
Text
id pubmed-9931714
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-99317142023-02-17 Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue Kröz, M. Quittel, F. Reif, M. Zerm, R. Pranga, D. Bartsch, C. Brinkhaus, B. Büssing, A. Gutenbrunner, C. Sci Rep Article Cancer-related fatigue (CRF) is a frequent long-term symptom in non-metastasized breast cancer patients (BC). This 4-year follow-up intended to compare the long-term effects of a 10-week multimodal therapy (MT: sleep education, psychoeducation, eurythmy- and painting therapy) and combination therapy [CT: MT plus aerobic training (AT)] to AT-control. BC-patients were randomized or allocated by preference to three arms in a comprehensive cohort study. Primary outcome was a composite score including Pittsburgh Sleep Quality Index (PSQI) and Cancer Fatigue Scale (CFS-D), captured at baseline, after 10 weeks of intervention (T1), 6 months later (T2), and after 4 years (T3). We exploratively tested for superiority of MT and CT versus AT after 4 years (T3) based on the statistical model of the main analysis. Of 126 (65 randomized) BC-patients included, 105 started treatments and 79 were re-assessed for long-term effects (T3). MT and CT were superior over AT after 4 years regarding PSQI/CFS-D and PSQI sum-score, respectively (all p < 0.05), but not for CFS-D. The multimodal and combination treatment for breast cancer patients with CRF indicates sustainable long-term superiority over aerobic training for the outcomes sleep quality and combined sleep quality/fatigue. A confirmative randomized controlled trial is warranted. Nature Publishing Group UK 2023-02-15 /pmc/articles/PMC9931714/ /pubmed/36792620 http://dx.doi.org/10.1038/s41598-022-25322-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kröz, M.
Quittel, F.
Reif, M.
Zerm, R.
Pranga, D.
Bartsch, C.
Brinkhaus, B.
Büssing, A.
Gutenbrunner, C.
Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title_full Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title_fullStr Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title_full_unstemmed Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title_short Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
title_sort four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931714/
https://www.ncbi.nlm.nih.gov/pubmed/36792620
http://dx.doi.org/10.1038/s41598-022-25322-y
work_keys_str_mv AT krozm fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT quittelf fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT reifm fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT zermr fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT prangad fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT bartschc fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT brinkhausb fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT bussinga fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT gutenbrunnerc fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue
AT fouryearfollowuponfatigueandsleepqualityofathreearmedpartlyrandomizedcontrolledstudyinbreastcancersurvivorswithcancerrelatedfatigue